Abstract HLA-DM (abbreviated DM) is an MHC-encoded glycoprotein that catalyzes the
selective release of peptides, including class II-associated invariant chain peptides, from …

Abstract HLA-DM (DM) is a heterodimeric MHC molecule that catalyzes the peptide loading
of classical MHC class II molecules in the endosomal/lysosomal compartments of APCs …

During maturation of MHC II molecules, newly synthesized and assembled complexes of
MHC II αβ dimers with invariant chain (Ii) are targeted to endosomes, where Ii is proteolyzed …

Considerable progress has been made in the field of major histocompatibility complex
(MHC) class II-restricted antigen presentation. The analysis of mutant cell lines defective in …

Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …

Abstract HLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound
peptides in endocytic compartments and stabilizes empty MHCII molecules. Crystal …

Human HLA-DM or mouse H2-DM plays a vital role for presentation of antigenic sequences
by MHC class II peptide receptors. These non-classical MHC class II molecules catalyze the …

HLA-DM (DM) is a non-classical major histocompatibility complex (MHC) class II molecule
that interacts with classical MHC II molecules in acidic compartments. During this …

Abstract HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical
MHC II molecules in acidic compartments. During this association DM is supposed to …

HLA-DM catalyzes the release of MHC class II–associated invariant chain–derived peptides
(CLIP) from class II molecules. Recent evidence has suggested that HLA-DO is a negative …