Identification of differentially methylated regions in new genes associated with knee osteoarthritis
Epigenetic changes in articular chondrocytes are associated with osteoarthritis (OA) disease
progression. Numerous studies have identified differentially methylated cytosines in OA …
progression. Numerous studies have identified differentially methylated cytosines in OA …
Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2014 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
Analysis of mRNA expression and DNA methylation datasets according to the genomic distribution of CpG sites in osteoarthritis
P Yi, X Xu, J Yao, B Qiu - Frontiers in Genetics, 2021 - frontiersin.org
Objectives Transcriptional changes in cartilage can impact function by causing degradation
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …
Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2016 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …
methylation patterns in subchondral bone underlying eroded and intact cartilage from …
[PDF][PDF] Characterization of the cartilage DNA methylome in knee and hip osteoarthritis
MD Rushton, LN Reynard, MJ Barter… - Arthritis & …, 2014 - Wiley Online Library
Objective The aim of this study was to characterize the genome‐wide DNA methylation
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …
Genome‐wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes
SEB Taylor, YH Li, WH Wong… - Arthritis & …, 2015 - Wiley Online Library
Objective To examine the genome‐wide distribution of hydroxymethylated cytosine (5hmC)
in osteoarthritic (OA) and normal chondrocytes in order to investigate the effect on OA …
in osteoarthritic (OA) and normal chondrocytes in order to investigate the effect on OA …
Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage
O Alvarez‐Garcia, KM Fisch… - Arthritis & …, 2016 - Wiley Online Library
Objective To analyze the methylome of normal and osteoarthritic (OA) knee articular
cartilage and to determine the role of DNA methylation in the regulation of gene expression …
cartilage and to determine the role of DNA methylation in the regulation of gene expression …
Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in …
E Aref-Eshghi, Y Zhang, M Liu, PE Harper… - BMC musculoskeletal …, 2015 - Springer
Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …
Identification of DNA methylation changes associated with disease progression in subchondral bone with site-matched cartilage in knee osteoarthritis
Y Zhang, N Fukui, M Yahata, Y Katsuragawa… - Scientific Reports, 2016 - nature.com
Subchondral bone plays a key role in the development of osteoarthritis, however,
epigenetics of subchondral bone has not been extensively studied. In this study, we …
epigenetics of subchondral bone has not been extensively studied. In this study, we …
Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients
J Fernández-Tajes, A Soto-Hermida… - Annals of the …, 2014 - ard.bmj.com
Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …