From mundane to classic: Sinomenine as a multi‐therapeutic agent

D Li, Z Zhong, CN Ko, T Tian… - British Journal of …, 2023 - Wiley Online Library
Sinomenine is an active substance extracted from the traditional Chinese medicine
Sinomenium acutum. Sinomenine has been shown to mediate a wide range of …

[HTML][HTML] Potential therapeutic effects and pharmacological evidence of sinomenine in central nervous system disorders

H Hong, X Lu, Q Lu, C Huang, Z Cui - Frontiers in Pharmacology, 2022 - frontiersin.org
Sinomenine is a natural compound extracted from the medicinal plant Sinomenium acutum.
Its supplementation has been shown to present benefits in a variety of animal models of …

A systematic review on the sinomenine derivatives

J Tang, A Raza, J Chen, H Xu - Mini reviews in medicinal …, 2018 - ingentaconnect.com
Sinomenine is one of the most widely known alkaloids owing to different therapeutic
properties including anti-inflammatory and immunosuppressive activities, as well as the …

The present and future synthetic strategies of structural modifications of sinomenine

JPL Ng, P Coghi, BYK Law, L Liu… - Organic Chemistry …, 2020 - pubs.rsc.org
Sinomenine is a tetracyclic alkaloid that is extracted from the traditional Chinese medicine
sinomenium acutum. It has been reported to possess low cytotoxicity and a variety of …

A review on pharmacokinetics of sinomenine and its anti-inflammatory and immunomodulatory effects

S Wang, L Zhang, Y Zhou, Z Liu, Z Zhou… - International …, 2023 - Elsevier
Autoimmune diseases (ADs), with significant effects on morbidity and mortality, are a broad
spectrum of disorders featured by body's immune responses being directed against its own …

Determination of sinomenine in human plasma by HPLC/ESI/ion trap mass spectrum

YM Yao, ZR Tan, ZY Hu, X Guo, ZN Cheng, LS Wang… - Clinica chimica acta, 2005 - Elsevier
BACKGROUND: Sinomenine is a pure alkaloid with a variety of pharmacological actions
including anti-inflammation, immuno-suppression, analgesia, antihypertension, and …

[HTML][HTML] Towards better sinomenine-type drugs to treat rheumatoid arthritis: Molecular mechanisms and structural modification

C Zhang, S Zhang, J Liao, Z Gong, X Chai, H Lyu - Molecules, 2022 - mdpi.com
Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in
the early 1920s and has since attracted special interest as a potential anti-rheumatoid …

[HTML][HTML] HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats

L Long, P Wu, X Chen, Z Zhang, Y Chen, Y Li… - Acta Pharmacologica …, 2010 - nature.com
Aim: To improve and validate analytical methods based on HPLC and liquid
chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI …

The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitro

ZQ Liu, K Chan, H Zhou, ZH Jiang, YF Wong, HX Xu… - Life sciences, 2005 - Elsevier
Sinomenine, an alkaloid derived from the Chinese medical plant Sinomenium acutum, was
studied with regard to its pharmacokinetics and tissue distribution in rats, and to its protein …

[HTML][HTML] Recent advancements in drug delivery of sinomenine, A disease-modifying anti-rheumatic drug

X Chen, C Lu, Y Duan, Y Huang - Pharmaceutics, 2022 - mdpi.com
Sinomenine (SIN) is a benzyltetrahydroisoquinoline-type alkaloid isolated from the dried
plant root and stem of Sinomenium acutum (Thumb.) Rehd. et Wils, which shows potent anti …