Parkinson's disease is primarily characterized by diminished dopaminergic function;
however, the impact of these impairments on large-scale brain dynamics remains unclear. It …

Altered brain connectivity has been described in people with Parkinson's disease and in
response to dopaminergic medications. However, it is unclear whether dopaminergic …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by dopamine depletion in the striatum. One consistent pathophysiological hallmark of PD is …

The effects of dopaminergic therapy for Parkinson's disease (PD) on the brain functional
architecture are still unclear. We investigated this topic in 31 PD patients (disease duration …

Background Resting-state functional magnetic resonance imaging (fMRI) studies have
demonstrated that basal ganglia functional connectivity is altered in Parkinson's disease …

Parkinson's disease (PD) is a neurodegenerative disorder primarily affecting the aging
population. The neurophysiological mechanisms underlying parkinsonian symptoms remain …

Changes in effective connectivity during the performance of a motor task appear important
for the pathogenesis of motor symptoms in Parkinson's disease (PD). One type of task that is …

Parkinson's disease (PD) leads to dysfunction in multiple cortico-striatal circuits. The
neurodegeneration has also been associated with impaired white matter integrity. This …

Parkinson's disease (PD) is a neurodegenerative disease, neuropathologically
characterized by progressive loss of neurons in distinct brain areas. We hypothesize that …

Although alterations in resting-state functional connectivity between brain regions have
previously been reported in Parkinson's disease, the spatial organization of these changes …