Aims/hypothesis We aimed to investigate whether the impact of obesity and unfavourable
lifestyle on type 2 diabetes risk is accentuated by genetic predisposition. Methods We …

Aims/hypothesis Studying gene–lifestyle interaction may help to identify lifestyle factors that
modify genetic susceptibility and uncover genetic loci exerting important subgroup effects …

Aims/hypothesis Obesity is a major risk factor for type 2 diabetes. Recent genome-wide
association (GWA) studies have identified multiple loci robustly associated with BMI and risk …

In this study, Wareham and colleagues quantified the combined effects of genetic and
lifestyle factors on risk of T2D in order to inform strategies for prevention. The authors found …

Aims/hypothesis Although a family history of type 2 diabetes is a strong risk factor for the
disease, the factors mediating this excess risk are poorly understood. In the InterAct case …

OBJECTIVE Over 30 loci have been associated with risk of type 2 diabetes at genome-wide
statistical significance. Genetic risk scores (GRSs) developed from these loci predict …

OBJECTIVE: To investigate the interaction of a family history of diabetes with obesity and
physical inactivity on diabetes prevalence in middle-aged and elderly men and women …

OBJECTIVE Recent advances in type 2 diabetes genetics have culminated in the discovery
and confirmation of multiple risk variants. Two important and largely unanswered questions …

Background Type 2 diabetes mellitus is thought to develop from an interaction between
environmental and genetic factors. We examined whether clinical or genetic factors or both …

Background Whether genetic susceptibility to type 2 diabetes is modified by a healthy
lifestyle among Chinese remains unknown. Objectives The aim of the study was to …