Progesterone is critical for the establishment and the maintenance of pregnancy, both by its
endocrine and immunological effects. The genomic actions of progesterone are mediated by …

Progesterone is crucial for the establishment and maintenance of pregnancy. Progesterone-
regulated genes in the pregnant uterus control the development of endometrial receptivity as …

In the presence of progesterone, lymphocytes from pregnant females produce an
immunomodulatory protein known as progesterone induced blocking factor (PIBF). We …

Immunosuppression by Progesterone in Pregnancy describes a newly discovered feto-
protective mechanism resulting from the interaction of the immune and endocrine systems …

Steroid refractory inflammation is an unmet medical need in the management of
inflammatory diseases. Thus, mechanisms, improving steroid sensitivity and simultaneously …

Progesterone is an essential hormone in the process of reproduction. It is involved in the
menstrual cycle, implantation and is essential for pregnancy maintenance. It has been …

It is becoming increasingly clear that endogenous sex steroids are key players in a range of
inflammatory contexts. Androgens and estrogens have been shown to have a profound …

We have recently demonstrated that 17β-estradiol (E2) opposes cytokine-dependent
increase of inducible nitric oxide synthase (iNOS) activity in rat smooth muscle cells and …

The anti-inflammatory properties of glucocorticoids are attributed in part, to their interference
with prostaglandin synthesis. Phospholipases A2 and cyclooxygenases, the key enzymes of …

Natural progesterone (P4) has a unique pharmacodynamic activity and safety profile
compared to the synthetic progestins. As a result, a class effect does not exist for both P4 …