Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease—Clinical and Pre-Clinical Overview and Systematic Review of the Literature

F Ionita-Radu, C Patoni, AS Nancoff, FS Marin… - International Journal of …, 2024 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the predominant cause of chronic liver
conditions, and its progression is marked by evolution to non-alcoholic steatosis …

Berberine prevents NAFLD and HCC by modulating metabolic disorders

X Lin, J Zhang, Y Chu, Q Nie, J Zhang - Pharmacology & Therapeutics, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a global metabolic disease with high
prevalence in both adults and children. Importantly, NAFLD is becoming the main cause of …

Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high‐fat diet‐induced nonalcoholic steatohepatitis

J Li, Z Liu, M Guo, K Xu, M Jiang, A Lu… - Evidence‐Based …, 2015 - Wiley Online Library
Objective. Berberine has been used to treat nonalcoholic steatohepatitis (NASH), which has
been addressed in many studies. In this study, we investigated the molecular pharmacology …

The therapeutic effect of berberine in the treatment of nonalcoholic fatty liver disease: A meta‐analysis

X Wei, C Wang, S Hao, H Song… - … and Alternative Medicine, 2016 - Wiley Online Library
Aim. To assess the efficacy of berberine in the treatment of nonalcoholic fatty liver disease
through meta‐analysis. Method. We searched Embase, Pubmed, Cochrane Library, and so …

Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut …

S Yang, S Cao, C Li, J Zhang, C Liu, F Qiu… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a major public health problem in many
countries. Berberine (BBR) is an effective therapeutic agent in alleviating NAFLD …

Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism

X Ma, X Yu, R Li, J Cui, H Yu, L Ren, J Jiang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Berberine (BBR) and silybin (SIY) are natural compounds
obtained from Berberidaceae members and Silybum marianum (L.) Gaertn., respectively …

Berberine prevents disease progression of nonalcoholic steatohepatitis through modulating multiple pathways

Y Wang, YL Tai, D Zhao, Y Zhang, J Yan, G Kakiyama… - Cells, 2021 - mdpi.com
Background and Aims: The disease progression of nonalcoholic fatty liver disease (NAFLD)
from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is driven by multiple …

Berberine ameliorates nonalcoholic fatty liver disease by a global modulation of hepatic mRNA and lncRNA expression profiles

X Yuan, J Wang, X Tang, Y Li, P Xia, X Gao - Journal of translational …, 2015 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is a common liver disorder that
currently lacks effective treatment. Berberine (BBR), a botanic compound isolated from …

Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells

Y Sun, X Yuan, F Zhang, Y Han, X Chang, X Xu, Y Li… - Scientific Reports, 2017 - nature.com
Oxidative stress is thought to be critical for the pathogenesis of hepatic steatosis and its
progress to non-alcoholic steatohepatitis. Berberine (BBR) can improve hepatic steatosis. In …

Berberine ameliorates non‑alcoholic steatohepatitis in ApoE-/-mice

J Yang, XJ Ma, L Li, L Wang… - Experimental and …, 2017 - spandidos-publications.com
The aim of the present study was to explore the protective effects of Berberine (BBR) against
non‑alcoholic steatohepatitis (NASH). Male 4‑week‑old C57BL/6J Apolipoprotein E‑deficient …