Dynamics of CD81 expression on lymphocyte subsets during interferon-α-based antiviral treatment of patients with chronic hepatitis C
B Kronenberger, E Herrmann… - Journal of leukocyte …, 2006 - academic.oup.com
CD81 is a hepatitis C virus (HCV) coreceptor with important functions in lymphocytes. During
treatment, CD81 expression may be changed directly by the antiviral therapy or indirectly by …
treatment, CD81 expression may be changed directly by the antiviral therapy or indirectly by …
Mutations within the CD81-Binding Sites and Hypervariable Region 2 of the Envelope 2 Protein: Correlation with Treatment Response in Hepatitis C Virus–Infected …
WP Hofmann, C Sarrazin… - The Journal of …, 2003 - academic.oup.com
The hepatitis C virus (HCV) envelope 2 (E2) protein interacts with the cellular receptor CD81
in vitro. Within E2, 2 CD81-binding sites were described. E2-CD81 interaction has been …
in vitro. Within E2, 2 CD81-binding sites were described. E2-CD81 interaction has been …
Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model
JR Lukens, MW Cruise, MG Lassen… - The Journal of …, 2008 - journals.aai.org
The impaired function of CD8+ T cells is characteristic of hepatitis C virus (HCV) persistent
infection. HCV core protein has been reported to inhibit CD8+ T cell responses. To …
infection. HCV core protein has been reported to inhibit CD8+ T cell responses. To …
Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver
Background/Aims: Association of hepatitis C virus (HCV) with increased autoantibodies,
mixed cryoglobulinaemia, non-Hodgkin's B-cell lymphoma and increased peripheral innate …
mixed cryoglobulinaemia, non-Hodgkin's B-cell lymphoma and increased peripheral innate …
Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81
Y Sagi, A Landrigan, R Levy… - Proceedings of the …, 2012 - National Acad Sciences
Cluster of differentiation 81 (CD81) is a widely expressed tetraspanin molecule that
physically associates with CD4 and CD8 on the surface of human T cells. Coengagement of …
physically associates with CD4 and CD8 on the surface of human T cells. Coengagement of …
CD28–negative CD8–positive cytotoxic T lymphocytes mediate hepatocellular damage in Hepatitis C virus infection
K Kurokohchi, T Masaki, K Arima, Y Miyauchi… - Journal of clinical …, 2003 - Springer
The pathogenic mechanism for hepatocellular damage in hepatitis C virus (HCV) infection
has not been clearly understood. Analysis of costimulatory molecules on lymphocytes may …
has not been clearly understood. Analysis of costimulatory molecules on lymphocytes may …
Antiviral treatment down-regulates peripheral B-cell CD81 expression and CD5 expansion in chronic hepatitis C virus infection
E Zuckerman, A Kessel, G Slobodin, E Sabo… - Journal of …, 2003 - Am Soc Microbiol
Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation. Recently, CD81 was identified as an HCV receptor on B …
cell lymphoproliferation. Recently, CD81 was identified as an HCV receptor on B …
The response to TLR ligation of human CD16+ CD14− monocytes is weakly modulated as a consequence of persistent infection with the hepatitis C virus
C Peng, BS Liu, RJ de Knegt, HLA Janssen… - Molecular …, 2011 - Elsevier
Little is known about the frequency and function of CD16+ CD14− monocytes from chronic
HCV patients. We observed that the absolute numbers and ratio of CD16+ CD14− to CD14+ …
HCV patients. We observed that the absolute numbers and ratio of CD16+ CD14− to CD14+ …
HCV epitope, homologous to multiple human protein sequences, induces a regulatory T cell response in infected patients
PT Losikoff, S Mishra, F Terry, A Gutierrez, MT Ardito… - Journal of …, 2015 - Elsevier
Background & Aims Spontaneous resolution of hepatitis C virus (HCV) infection depends
upon a broad T cell response to multiple viral epitopes. However, most patients fail to clear …
upon a broad T cell response to multiple viral epitopes. However, most patients fail to clear …
Role of conserved E2 residue W420 in receptor binding and hepatitis C virus infection
VM Cowton, AGN Angus, SJ Cole… - Journal of …, 2016 - Am Soc Microbiol
Hepatitis C virus (HCV) enters cells via interactions with several host factors, a key one
being that between the viral E2 envelope glycoprotein and the CD81 receptor. We …
being that between the viral E2 envelope glycoprotein and the CD81 receptor. We …