Hepatitis C virus (HCV) is one of the leading causes of chronic liver diseases and B-
lymphocyte proliferative disorders, including mixed cryoglobulinemia and B-cell lymphoma …

Dendritic cells (DCs) isolated from patients with chronic hepatitis C virus (HCV) infection
display an impaired capacity to generate type 1 CD4+ T cell immunity. Several reports have …

Virus-specific CD4+ T cells play a major role in viral infections, such as hepatitis C virus
(HCV). Viral clearance is associated with vigorous and multi-specific CD4+ T-cell responses …

Limited information is available regarding hepatitis C virus (HCV) entry events. Viral
attachment and infection studies have been performed using HCV envelope glycoprotein …

A timely, efficient, and coordinated activation of both CD4 and CD8 T cell subsets following
HCV infection is believed to be essential for HCV control. However, to what extent a failure …

BACKGROUND/AIMS: Hepatitis C virus leads to chronic hepatitis in the majority of infected
individuals. The mechanism of viral persistence is not completely understood. Hepatitis C …

Evasion from protective CD8 responses by mutations within immunodominant epitopes
represents a potential strategy of HCV persistence. To investigate the pathogenetic …

Introduction Most T lymphocytes, including regulatory T cells, express the CD27
costimulatory receptor in steady state conditions. There is evidence that CD27 engagement …

Aim The lack of potent innate immune responses during HCV infection might lead to a delay
in initiating adaptive immune responses. Kupffer cells (KCs) and liver-infiltrating monocytes …

BACKGROUND & AIMS: Hepatitis C virus (HCV) is remarkably successful in establishing
persistent infections due to its ability to evade host immune responses through a …