We measured oxygen consumption in the exercising lower limb by using noninvasive tissue
oximetry with the near-infrared spectra of hemoglobin in the quadriceps muscle during …

Background: The authors hypothesized that impaired oxygen extraction in mitochondrial
myopathy (MM) results in a high oxygen saturation in venous effluent blood from working …

Metabolic myopathies due to a variety of enzymatic deficiencies are well recognized. The
dynamics of oxygen delivery and utilization during exercise have not been observed …

Two patients with mitochondrial encephalomyopathy due to complexes I and IV deficiencies
received 150 mg/d of coenzyme Q10 (CoQ). We studied them with a bicycle ergometer …

A cardinal feature of impaired skeletal muscle oxidative metabolism in mitochondrial
myopathies is a limited ability to increase the extraction of O2 from blood relative to the …

The aim of the study was to determine the sensitivity and specificity of the lactate stress test
in the detection of mitochondrial myopathies. Thirty one healthy subjects, 10 patients with …

Five patients with chronic progressive external ophthalmoplegia (CPEO) and 27 healthy
controls were examined by near-infrared spectroscopy (NIRS) for the noninvasive and direct …

The dynamics of oxygen delivery and utilization are examined in a variety of mitochondrial
disorders during rest, exercise and post exercise. We used a non-invasive optical technique …

Increased oxygen transport by the circulation is normally tightly coupled to increased oxygen
uptake (VO2) during exercise; cardiac output (Q) increases 5 to 6 liters for every liter of …

Five patients with chronic progressive external ophthalmoplegia (CPEO) and 27 healthy
controls were examined by near‐infrared spectroscopy (NIRS) for the noninvasive and direct …