Hyperphosphorylation at the Y705 residue of signal transducer and activator of transcription
3 (STAT3) is implicated in tumorigenesis of leukemia and some solid tumors. However, its …

STAT3 is constitutively activated in colon cancer but its contributions in cancer-initiating cells
have not been explored. In this study, we characterized STAT3 in aldehyde dehydrogenase …

Colorectal carcinoma (CRC) is a major cause of morbidity and mortality in Western
countries. It has so far been molecularly defined mainly by alterations of the Wnt pathway …

Abnormalities in the signal transducer and activator of transcription (STAT) pathway are
involved in the oncogenesis of several cancers. However, the mechanism by which …

Signal transducers and activators of transcription (STAT) are a highly conserved family of
transcription factors that are activated by phosphorylation in the cytoplasm, after which they …

The role of STAT1 and STAT3 for colorectal carcinoma (CRC) development and progression
is controversial. We evaluated 414 CRC patient samples on tissue microarrays for …

In developed countries, colorectal cancer (CRC) is the fourth most common cancer and the
second leading cause of malignant-related deaths. CRC is treatable cancer when …

Signal transducer and activator of transcription 6 (STAT6) is a member of the STAT family of
proteins that serve key roles in the initiation of tumorigenesis and malignant transformation …

STAT1/STAT3 transcription factors are important regulators for development of normal,
infected or inflammed cells. They are also critically involved in the progression of various …

The signal transducer and activator of transcription (STAT) family of proteins was originally
discovered in the context of normal cell biology where they function to transduce intracellular …