Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR 1), not G‐Protein‐Coupled Receptor 1 (GPR 1), in Human and Rat Vasculature

AJ Kennedy, P Yang, C Read, RE Kuc… - Journal of the …, 2016 - Am Heart Assoc
Background Circulating levels of chemerin are significantly higher in hypertensive patients
and positively correlate with blood pressure. Chemerin activates chemokine‐like receptor 1 …

Chemerin promotes angiogenesis in vivo

N Nakamura, K Naruse, Y Kobayashi… - Physiological …, 2018 - Wiley Online Library
Chemerin acts as a chemotactic factor for leukocyte populations expressing the G protein‐
coupled receptor CMKLR 1 (ChemR23). It is also an adipocytokine involved in obesity and …

Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis

J Kaur, R Adya, BK Tan, J Chen… - … and biophysical research …, 2010 - Elsevier
Chemerin acting via its distinct G protein-coupled receptor CMKLR1 (ChemR23), is a novel
adipokine, circulating levels of which are raised in inflammatory states. Chemerin shows …

Chemerin-induced arterial contraction is Gi-and calcium-dependent

DJ Ferland, ES Darios, RR Neubig, B Sjögren… - Vascular …, 2017 - Elsevier
Chemerin is an adipokine associated with increased blood pressure, and may link obesity
with hypertension. We tested the hypothesis that chemerin-induced contraction of the …

Chemerin connects fat to arterial contraction

SW Watts, AM Dorrance, ME Penfold… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Obesity and hypertension are comorbid in epidemic proportion, yet their
biological connection is largely a mystery. The peptide chemerin is a candidate for …

International union of basic and clinical pharmacology CIII: chemerin receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) nomenclature, pharmacology, and …

AJ Kennedy, AP Davenport - Pharmacological Reviews, 2018 - ASPET
Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous
ligand for a G protein–coupled receptor encoded by the gene CMKLR1 (also known as …

[HTML][HTML] Renal chemerin expression is induced in models of hypertensive nephropathy and glomerulonephritis and correlates with markers of inflammation and …

A Mocker, KF Hilgers, N Cordasic, R Wachtveitl… - International journal of …, 2019 - mdpi.com
Chemerin and its receptor, chemokine-like receptor 1 (CmklR1), are associated with
chemotaxis, inflammation, and endothelial function, especially in metabolic syndrome …

Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure

H Kunimoto, K Kazama, M Takai… - American Journal …, 2015 - journals.physiology.org
Blood chemerin concentration shows positive correlation not only with body mass index and
serum triglyceride level but also with systolic blood pressure. While it seems likely that …

[HTML][HTML] Chemerin and CMKLR1 expression in human arteries and periadventitial fat: a possible role for local chemerin in atherosclerosis?

CG Kostopoulos, SG Spiroglou, JN Varakis… - BMC Cardiovascular …, 2014 - Springer
Background Depending on their anatomical location, different fat depots have a different
capacity to produce bioactive peptides, called adipokines. Adipokines produced by …

Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary …

A Omori, M Goshima, C Kakuda, T Kodama… - … -European Journal of …, 2020 - Springer
Chemerin is an adipocytokine having cardiovascular effects. Chemokine-like receptor 1
(CMKLR1) and chemokine (CC motif) receptor-like 2 (CCRL2) are chemerin receptors …