[HTML][HTML] The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension

SW Watts, ES Darios, AE Mullick, H Garver… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Measures of the adipokine chemerin are elevated in multiple cardiovascular diseases,
including hypertension, but little mechanistic work has been done to implicate chemerin as …

Chemerin regulates crosstalk between adipocytes and vascular cells through Nox

KB Neves, A Nguyen Dinh Cat, RAM Lopes, FJ Rios… - …, 2015 - Am Heart Assoc
Adipocytes produce adipokines, including chemerin, a chemoattractant that mediates effects
through its ChemR23 receptor. Chemerin has been linked to endothelial dysfunction and …

Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive and Akt-dependent pathways

KB Neves, A Nguyen Dinh Cat… - American Journal …, 2018 - journals.physiology.org
Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been
associated with endothelial dysfunction, inflammation, and insulin resistance. However, the …

[HTML][HTML] Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 …

ET Wargent, MS Zaibi, JF O'Dowd, MA Cawthorne… - PeerJ, 2015 - peerj.com
The literature is unclear on whether the adipokine chemerin has pro-or anti-inflammatory
properties or plays any role in the aetiology of type 2 diabetes or obesity. To address these …

Chemerin inhibits vascular calcification through ChemR23 and is associated with lower coronary calcium in chronic kidney disease

M Carracedo, A Witasp, AR Qureshi… - Journal of Internal …, 2019 - Wiley Online Library
Background Chemerin is an adipokine that signals through the G protein‐coupled receptor
ChemR23 and is associated with inflammation, glucose homeostasis, lipid metabolism and …

[HTML][HTML] Chemerin induces endothelial cell inflammation: activation of nuclear factor-kappa beta and monocyte-endothelial adhesion

GK Dimitriadis, J Kaur, R Adya, AD Miras, HS Mattu… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Chemerin, a chemoattractant protein, acts via a G-protein coupled chemokine receptor, ie
Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory …

[HTML][HTML] Effects of chemerin/CMKLR1 in obesity-induced hypertension and potential mechanism

C Weng, Z Shen, X Li, W Jiang, L Peng… - American Journal of …, 2017 - ncbi.nlm.nih.gov
Background: Obesity-induced hypertension (OIH) has a high morbidity and mortality, and its
prevention and treatment has been a major challenge in clinical practice. Chemerin is a …

Chemerin as a driver of hypertension: a consideration

DJ Ferland, AE Mullick, SW Watts - American journal of …, 2020 - academic.oup.com
The protein chemerin (tazarotene-induced gene, TIG2; RARRES2) is a relatively new
adipokine. Many studies support that circulating chemerin levels associate strongly and …

Chemerin-9, a potent agonist of chemerin receptor (ChemR23), prevents atherogenesis

K Sato, H Yoshizawa, T Seki, R Shirai… - Clinical …, 2019 - portlandpress.com
Plasma levels of chemerin, an adipocytokine produced from the adipose tissues and liver,
are associated with metabolic syndrome and coronary artery disease (CAD). Chemerin and …

Chemerin: a comprehensive review elucidating the need for cardiovascular research

DJ Ferland, SW Watts - Pharmacological research, 2015 - Elsevier
When chemerin was discovered in 1997, it was relegated to being a protein associated with
the normal skin function contrasting the setting of psoriasis. However, with the discovery of …