Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury

SK Agrawal, E Theriault, MG Fehlings - Journal of neurotrauma, 1998 - liebertpub.com
Metabotropic glutamate receptors (mGluRs) participate in glutamate neural transmission, but
their role in the pathophysiology of spinal cord injury (SCI) has not been explored …

Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain

CD Mills, KM Johnson, CE Hulsebosch - Journal of neurotrauma, 2002 - liebertpub.com
Spinal cord injury (SCI) initiates a cascade of biochemical events that leads to an increase in
extracellular excitatory amino acid (EAA) concentrations, which results in glutamate receptor …

Role of group II and group III metabotropic glutamate receptors in spinal cord injury

CD Mills, KM Johnson, CE Hulsebosch - Experimental neurology, 2002 - Elsevier
Spinal cord injury (SCI) produces an increase in extracellular excitatory amino acid (EAA)
concentrations that results in glutamate receptor-mediated excitotoxic events. An important …

Changes in metabotropic glutamate receptor expression following spinal cord injury

CD Mills, SD Fullwood, CE Hulsebosch - Experimental neurology, 2001 - Elsevier
Spinal cord injury (SCI) initiates biochemical events that lead to an increase in extracellular
excitatory amino acid concentrations, resulting in glutamate receptor-mediated excitotoxic …

Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury

A Mukhin, L Fan, AI Faden - Journal of Neuroscience, 1996 - Soc Neuroscience
The role of phospholipase C-coupled (group I) metabotropic glutamate receptors (mGluR1
and mGluR5) in post-traumatic neuronal injury was examined using rat in vivo and in vitro …

Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat

CD Mills, GY Xu, DJ McAdoo… - Journal of …, 2001 - Wiley Online Library
Spinal cord injury (SCI) leads to an increase in extracellular excitatory amino acid (EAA)
concentrations resulting in glutamate receptor‐mediated excitotoxic events. The glutamate …

Neuroprotective effects of group III mGluR in traumatic neuronal injury

AI FADEN, SA IVANOVA, AG YAKOVLEV… - Journal of …, 1997 - liebertpub.com
We have used an in vitro trauma model to examine the effects of modulation of group III
metabotropic glutamate receptors (mGluR) on post-traumatic neuronal cell death. Rat …

Upregulation of Group I metabotropic glutamate receptors in neurons and astrocytes in the dorsal horn following spinal cord injury

YS Gwak, CE Hulsebosch - Experimental neurology, 2005 - Elsevier
Of the glutamate receptor types, the metabotropic glutamate receptors (mGluRs) are G
proteins coupled and can initiate a number of intracellular pathways leading to …

Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improves outcome after brain trauma

AI Faden, DM O'Leary, L Fan, W Bao, PGM Mullins… - Experimental …, 2001 - Elsevier
The effects of selective blockade of group I metabotropic glutamate receptor subtype 1
(mGluR1) on neuronal cell survival and post-traumatic recovery was examined using rat in …

Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents

KR Byrnes, B Stoica, A Riccio… - Annals of Neurology …, 2009 - Wiley Online Library
Objective Activation of metabotropic glutamate receptor 5 (mGluR5) has neuroprotective
properties in vitro and has been reported to limit postischemic lesion volume in vivo …