Hypoxic microenvironments and angiogenesis have been a focus of tumor research in
previous years. The aim of the the present study was to create a hypoxic model and observe …

Aims To determine whether hypoxia-inducible factor 1 (HIF-1) is specifically activated by
hypoxia in vitro in pancreatic cancer cells and correlated these findings with tumor …

The functional role of hypoxia-inducible factor (HIF)-3α in the development of hepatocellular
carcinoma (HCC) is not yet fully understood. The aim of the present study was to elucidate …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that plays a
central role in the hypoxic expression of various genes. Vascular endothelial growth factor …

Hypoxia-inducible factor 1α (HIF-1α) that regulates genes involved in response to hypoxia
and promotes neo-angiogenesis, is a transcriptional factor for vascular endothelial cell …

AIM: To study the effects of hypoxia-inducible factor-1α (HIF-1α) silencing on the proliferation
of hypoxic CBRH-7919 rat hepatoma cells. METHODS: The CBRH-7919 rat hepatoma cell …

Abstract Hypoxia-inducible factor 1 (HIF-1) is involved in tumor progression/metastasis and
activated in various cancers. Here we show that HIF-1α, which plays a major role in HIF-1 …

An experimental rat hepatocellular carcinoma (HCC) model was established using
diethylnitrosamine and N-nitrosomorpholine to induce carcinogenesis in Sprague-Dawley …

Background/aims Hypoxia microenvironment plays a crucial role during tumor progression
and it tends to exhibit poor prognosis and make resistant to various conventional therapies …

Abstract Background Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a
central role in biologic processes under hypoxic conditions, especially concerning tumor …