Background The plasminogen (PLG) activation system is composed by a series of serine
proteases, inhibitors and several binding proteins, which together control the temporal and …

Plasminogen, the proenzyme of serine protease plasmin, is a plasma glycoprotein
synthesized primarily in the liver, and its evolutionary origin in chordates remains unclear …

Plg (plasminogen), a member of the serine protease superfamily, is a key component
constituting the fibrinolytic system, and its evolutionary origin remains unknown during the …

Vertebrates evolved an endothelium-lined hemostatic system and a pump-driven
pressurized circulation with a finely-balanced coagulation cascade and elaborate blood …

Phylogenetic analysis of protease domains of the vertebrate plasminogen–prothrombin
family revealed two major subfamilies:(1) a subfamily containing macrophage-stimulating …

Vertebrate blood coagulation is controlled by a cascade containing more than 20 proteins.
The cascade proteins are found in the blood in their zymogen forms and when the cascade …

The distinguishing characteristic of vampire bat (Desmodus rotundus) salivary plasminogen
activators (DSPAs) is their strict requirement for fibrin as a cofactor. DSPAs consist of …

The fibrinolytic system provides an essential means to remove fibrin deposits and blood
clots. The actual protease responsible for this is plasmin, formed from its precursor …

The generation of plasmin by plasminogen (Pg) activators (PAs) is a physiologic process in
animals that dissolves blood clots and promotes wound healing, blood vessel growth, and …

The saliva of the blood-eating vampire bat Desmodus rotundus contains plasminogen
activators (PAs) that maintain the fluidity of the prey's blood by activating plasminogen and …