NLRP3 deletion protects from hyperoxia-induced acute lung injury
J Fukumoto, I Fukumoto… - … of Physiology-Cell …, 2013 - journals.physiology.org
Inspiration of a high concentration of oxygen, a therapy for acute lung injury (ALI), could
unexpectedly lead to reactive oxygen species (ROS) production and hyperoxia-induced …
unexpectedly lead to reactive oxygen species (ROS) production and hyperoxia-induced …
[HTML][HTML] NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1β
Y Mizushina, K Shirasuna, F Usui, T Karasawa… - Journal of Biological …, 2015 - ASBMB
Supplemental oxygen inhalation is frequently used to treat severe respiratory failure;
however, prolonged exposure to hyperoxia causes hyperoxic acute lung injury (HALI), which …
however, prolonged exposure to hyperoxia causes hyperoxic acute lung injury (HALI), which …
The selective Nlrp3 inflammasome inhibitor Mcc950 attenuates lung ischemia-reperfusion injury
KY Xu, CY Wu, S Tong, P Xiong, SH Wang - Biochemical and biophysical …, 2018 - Elsevier
Lung ischemia-reperfusion (IR) occurs in many circumstances and leads to impaired lung
function. The NACHT, LRR and PYD domains-containing protein 3 (Nlrp3) inflammasome is …
function. The NACHT, LRR and PYD domains-containing protein 3 (Nlrp3) inflammasome is …
ROS‐mediated NLRP3 inflammasome activity is essential for burn‐induced acute lung injury
S Han, W Cai, X Yang, Y Jia, Z Zheng… - Mediators of …, 2015 - Wiley Online Library
The NLRP3 inflammasome is necessary for initiating acute sterile inflammation. However, its
role in the pathogenesis of burn‐induced acute lung injury (ALI) is unknown. This study …
role in the pathogenesis of burn‐induced acute lung injury (ALI) is unknown. This study …
The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury
HD Jones, TR Crother… - American journal of …, 2014 - atsjournals.org
IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute
respiratory distress syndrome. We hypothesized that LPS and mechanical ventilation (MV) …
respiratory distress syndrome. We hypothesized that LPS and mechanical ventilation (MV) …
[HTML][HTML] Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury
D Li, W Ren, Z Jiang, L Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is characterized by
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …
NLRC5 negatively regulates inflammatory responses in LPS-induced acute lung injury through NF-κB and p38 MAPK signal pathways
Y Wang, C Huang, E Bian, T Lei, X Lv, J Li - Toxicology and Applied …, 2020 - Elsevier
Acute lung injury is an acute inflammatory disease with high morbidity rate and high
mortality rate. However, there is still no effective clinical treatment to date. Our previous …
mortality rate. However, there is still no effective clinical treatment to date. Our previous …
[HTML][HTML] Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury
X Rao, D Zhou, H Deng, Y Chen, J Wang, X Zhou… - Respiratory …, 2023 - Springer
Background Radiation-induced lung injury (RILI) is the most common and serious
complication of chest radiotherapy. However, reported radioprotective agents usually lead to …
complication of chest radiotherapy. However, reported radioprotective agents usually lead to …
Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS-induced acute lung injury
R Dhar, MN Rana, L Zhang, Y Li, N Li, Z Hu… - Free Radical Biology …, 2021 - Elsevier
Acute lung injury (ALI) is associated with overproduction of inflammatory mediators in lung
tissue. Previous studies have revealed that inflammation induces activation of …
tissue. Previous studies have revealed that inflammation induces activation of …
[HTML][HTML] Isoflurane attenuates lipopolysaccharide-induced acute lung injury by inhibiting ROS-mediated NLRP3 inflammasome activation
N Yin, Z Peng, B Li, J Xia, Z Wang, J Yuan… - American Journal of …, 2016 - ncbi.nlm.nih.gov
Nucleotide-binding domains and leucine-rich repeat (NLR) pyrin domains containing 3
(NLRP3) inflammasome are highly involved in the pathogenesis of acute lung injury (ALI) …
(NLRP3) inflammasome are highly involved in the pathogenesis of acute lung injury (ALI) …