Allelic variants of the MDR-1 gene have been shown recently to influence protein
expression and P-glycoprotein (P-gp) function in healthy volunteers. Therefore, 405 acute …

The expression of P-glycoprotein (P-gp), encoded by the MDR 1 gene, is an independent
adverse prognostic factor for response and survival in de novo acute myeloid leukemia …

In an attempt to determine the incidence and clinical relevance of mdr1 gene expression in
acute myeloid leukemia (AML), we examined 126 specimens obtained from adult patients …

The Multidrug Resistance gene (MDR 1) is frequently expressed in acute myeloid leukaemia
(AML). MDR 1 is associated with resistance to chemotherapy in vitro and with a poor …

The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane bound protein
that functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

By using RNase protection analysis, residues 2677 and 2995 of MDR-1 were identified as
sites of genetic polymorphism. Through use of oligonucleotide hybridization, the genomic …

Abstract Multidrug resistance‐1 (MDR‐1) gene single nucleotide polymorphisms (SNPs)
have been identified as associated with the treatment outcomes of acute myeloid leukemia …

MDR1 gene expression was examined in acute leukemia cells from 75 Japanese patients at
diagnosis (50 with acute myeloblastic leukemia [AML]: 10 M1, 18 M2, 5 M3, 8 M4, 9 M5; 25 …

By using a quantitative RNA-RNA solution hybridisation method, the average number of
mdr1 RNA transcripts per cell was measured in total nucleic acid extracts of leukaemic cells …

The clinical significance of the multidrug resistance (MDR 1) gene phenotype was
investigated in newly diagnosed AML and was compared with other clinical and biological …