In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
RR Avva, P Cresswell - Immunity, 1994 - cell.com
HLA-DR molecules associated with class II—associated invariant chain peptides (CLIP) are
generated in vivo as an intermediate in class II maturation. Such complexes can be …
generated in vivo as an intermediate in class II maturation. Such complexes can be …
HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
LK Denzin, C Hammond, P Cresswell - The Journal of experimental …, 1996 - rupress.org
Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM
expression accumulate class II molecules associated with residual invariant (I) chain …
expression accumulate class II molecules associated with residual invariant (I) chain …
Association between HLA-DM and HLA-DR in vivo
F Sanderson, C Thomas, J Neefjes, J Trowsdale - Immunity, 1996 - cell.com
The exchange of HLA class II–associated invariant chain peptides (CLIP) for cognate
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …
Editing of the HLA‐DR‐peptide repertoire by HLA‐DM.
H Kropshofer, AB Vogt, G Moldenhauer… - The EMBO …, 1996 - embopress.org
Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …
Determination of the HLA-DM interaction site on HLA-DR molecules
Abstract HLA-DM removes CLIP and other loosely bound peptides from MHC class II
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …
Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.
JM Riberdy, RR Avva, HJ Geuze… - The Journal of cell …, 1994 - rupress.org
We have compared the intracellular transport and subcellular distribution of MHC class II-
invariant chain complexes in a wild-type HLA-DR3 homozygous cell line and a mutant cell …
invariant chain complexes in a wild-type HLA-DR3 homozygous cell line and a mutant cell …
Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP
J Van Bergen, SP Schoenberger… - Proceedings of the …, 1997 - National Acad Sciences
The HLA class II-associated invariant chain (Ii)-derived peptide (CLIP) occupies the peptide
binding groove during assembly in the endoplasmic reticulum, travels with HLA class II to …
binding groove during assembly in the endoplasmic reticulum, travels with HLA class II to …
HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides
JM Riberdy, JR Newcomb, MJ Surman, JA Barbosat… - Nature, 1992 - nature.com
THE invariant chain, which associates with the major histocompatibility complex (MHC)
class II molecules in the endoplasmic reticulum, serves two functions important in antigen …
class II molecules in the endoplasmic reticulum, serves two functions important in antigen …
HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading
LK Denzin, P Cresswell - Cell, 1995 - cell.com
Human leukocyte antigen DM (HLA-DM) molecules are structurally related to classical MHC
class II molecules and reside in the lysosomallke compartment where class II-restricted …
class II molecules and reside in the lysosomallke compartment where class II-restricted …
Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.
AB Vogt, H Kropshofer… - Proceedings of the …, 1996 - National Acad Sciences
The nonclassical major histocompatibility complex class II molecule HLA-DM (DM) has
recently been shown to play a central role in the class II-associated antigen presentation …
recently been shown to play a central role in the class II-associated antigen presentation …