HLA-DR molecules associated with class II—associated invariant chain peptides (CLIP) are
generated in vivo as an intermediate in class II maturation. Such complexes can be …

Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM
expression accumulate class II molecules associated with residual invariant (I) chain …

The exchange of HLA class II–associated invariant chain peptides (CLIP) for cognate
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …

Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …

Abstract HLA-DM removes CLIP and other loosely bound peptides from MHC class II
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …

We have compared the intracellular transport and subcellular distribution of MHC class II-
invariant chain complexes in a wild-type HLA-DR3 homozygous cell line and a mutant cell …

The HLA class II-associated invariant chain (Ii)-derived peptide (CLIP) occupies the peptide
binding groove during assembly in the endoplasmic reticulum, travels with HLA class II to …

THE invariant chain, which associates with the major histocompatibility complex (MHC)
class II molecules in the endoplasmic reticulum, serves two functions important in antigen …

Human leukocyte antigen DM (HLA-DM) molecules are structurally related to classical MHC
class II molecules and reside in the lysosomallke compartment where class II-restricted …

The nonclassical major histocompatibility complex class II molecule HLA-DM (DM) has
recently been shown to play a central role in the class II-associated antigen presentation …