MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitro
MHC class I-restricted human melanoma epitope MART-127–35 specific TCR-engineered
CD4+ CD25− T cells synthesize Th1 type cytokines and exhibit cytolytic effector function …
CD4+ CD25− T cells synthesize Th1 type cytokines and exhibit cytolytic effector function …
CD4+ CD25− T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector …
Cytolytic T cell-centric active specific and adoptive immunotherapeutic approaches might
benefit from the simultaneous engagement of CD4+ T cells. Considering the difficulties in …
benefit from the simultaneous engagement of CD4+ T cells. Considering the difficulties in …
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR
CM Soto, JD Stone, AS Chervin, B Engels… - Cancer Immunology …, 2013 - Springer
Clinical studies with immunotherapies for cancer, including adoptive cell transfers of T cells,
have shown promising results. It is now widely believed that recruitment of CD4+ helper T …
have shown promising results. It is now widely believed that recruitment of CD4+ helper T …
[HTML][HTML] Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice
Z Hu, J Xia, W Fan, J Wargo, YG Yang - Oncotarget, 2016 - ncbi.nlm.nih.gov
A major factor hindering the exploration of adoptive immunotherapy in preclinical settings is
the limited availability of tumor-reactive human T cells. Here we developed a humanized …
the limited availability of tumor-reactive human T cells. Here we developed a humanized …
Human MHC Class I-restricted high avidity CD4+ T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo
In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-
Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lymphoma …
Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lymphoma …
Simultaneous Generation of CD8+ and CD4+ Melanoma-Reactive T Cells by Retroviral-Mediated Transfer of a Single T-Cell Receptor
Adoptive immunotherapy of cancer requires the generation of large numbers of tumor
antigen–reactive T cells for transfer into cancer patients. Genes encoding tumor antigen …
antigen–reactive T cells for transfer into cancer patients. Genes encoding tumor antigen …
Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers
G Bioley, C Jandus, S Tuyaerts, D Rimoldi… - The Journal of …, 2006 - journals.aai.org
Over the past decade, many efforts have been made to identify MHC class II-restricted
epitopes from different tumor-associated Ags. Melan-A/MART-1 26–35 parental or Melan …
epitopes from different tumor-associated Ags. Melan-A/MART-1 26–35 parental or Melan …
Redirecting human CD4+ T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR αβ gene transfer requires CD8α
R Willemsen, C Ronteltap, M Heuveling, R Debets… - Gene therapy, 2005 - nature.com
Adoptive immunotherapy involving the transfer of autologous tumor or virus-reactive T
lymphocytes has demonstrated its effectiveness in the eradication of cancer and virally …
lymphocytes has demonstrated its effectiveness in the eradication of cancer and virally …
TCR Gene Transfer: MAGE‐C2/HLA‐A2 and MAGE‐A3/HLA‐DP4 Epitopes as Melanoma‐Specific Immune Targets
T Straetemans, M Van Brakel… - Journal of …, 2012 - Wiley Online Library
Adoptive therapy with TCR gene‐engineered T cells provides an attractive and feasible
treatment option for cancer patients. Further development of TCR gene therapy requires the …
treatment option for cancer patients. Further development of TCR gene therapy requires the …
Effect of CD4+ CD25+ and CD4+ CD25− T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro
CD4+ T cells naturally expressing CD25 molecules (natural T regulatory cells (Tregs)) have
a role in maintaining self tolerance and in regulating responses to infectious agents …
a role in maintaining self tolerance and in regulating responses to infectious agents …