The means by which glucose stimulates insulin secretion from pancreatic β-cells has been
stud-ied for decades. Yet we still do not fully understand the cellular machinery underlying …

Nonselective cation channels may play a role in insulin secretion by regulating pancreatic β-
cell plasma membrane potential, Ca2+ homeostasis, and thereby glucose signaling …

There is now overwhelming evidence that TRP channels might play a significant role in the
regulation of insulin release from pancreatic β cells, which is until now insufficiently …

Pancreatic β-cell functions are regulated by a variety of endogenous and exogenous factors.
Calcium is one of the most potent triggers of β-cell growth, insulin production and exocytosis …

TRPM4 is a Ca2+-activated non-selective cation (CAN) channel that functions in cell
depolarization, which is important for Ca2+ influx and insulin secretion in pancreatic β-cells …

We recently proposed that the transient receptor potential melastatin 5 (TRPM5) cation
channel contributes to glucose-induced electrical activity of the β cell and positively …

Transient receptor potential channels have been put forward as regulators of insulin
secretion. A role for the TRPV1 ion channel in insulin secretion has been suggested in …

Objective Several studies have reported that the transient receptor potential melastatin–like
subtype 5 (TRPM5) channel, a Ca 2+-activated monovalent cation channel, is involved in …

Insulin secretion from pancreatic β-cells is the only efficient means to decrease blood
glucose concentrations. Glucose is the principal stimulator of insulin secretion with the ATP …

OBJECTIVE—Calcium-permeable cation channel TRPV2 is expressed in pancreatic β-cells.
We investigated regulation and function of TRPV2 in β-cells. RESEARCH DESIGN AND …