We suggest that cAMP is a key molecule in regulation of oocyte maturation. In the small
follicle, tonic levels of cAMP are continuously transferred to the oocytes to maintain meiotic …

The possible mediatory role of cAMP in the induction of oocyte maturation by luteinizing
hormone (LH) is not yet clear since evidence for both inhibitory and stimulatory actions of the …

The nature and functions of the chemical signals involved in the acquisition of competence
to resume meiosis, and the maintenance of meiotic arrest in antral follicles are the subjects …

The cyclic adenosine monophosphate (cAMP) content of intact oocyte‐cumulus cell
complexes at various times after the induction of oocyte maturation in mice in vivo was …

The hypothesis that cumulus cells inhibit oocyte maturation by a cAMP-dependent process
was tested (RM Schultz, R. Montgomery, PF Ward-Bailey, and JJ Eppig (1983). Dev. Biol …

Abstract cAMP synthesis by the rat oocyte and cumulus-oocyte complex was studied using
direct labeling techniques. Cumulus-oocyte complexes synthesized cAMP in response to …

Prior to ovulation, cell-to-cell communication between the oocyte and the cells of the
cumulus oophorus is terminated (NB Gilula, ML Epstein, and WH Beers, 1978, J. Cell Biol …

The original model for regulation of oocyte maturation proposed by us in 1978 postulated
that gap junction-mediated transmission of cAMP from the follicle cells to the oocyte inhibits …

We have developed an assay that can detect relative changes in the amount of a non-cAMP
inhibitor of maturation present in cumulus cells (Eppig et al., 1983, Dev. Biol., 100: 39-49) …

We have recently reported that the adenylate cyclase activator, forskolin, induces in the rat
ovarian follicle both cAMP accumulation and oocyte maturation. We demonstrate here, on …