Whom to biopsy: prediagnostic risk stratification with biomarkers, nomograms, and risk calculators

S Loeb, H Dani - Urologic Clinics, 2017 - urologic.theclinics.com
Historically, prostate biopsy was performed because of a prostate-specific antigen (PSA)
level exceeding a specific threshold or suspicious findings on digital rectal examination …

Defining prostate cancer risk before prostate biopsy

RP Pal, NU Maitra, JK Mellon, MA Khan - Urologic Oncology: Seminars and …, 2013 - Elsevier
Prostate cancer is the most commonly diagnosed cancer in men. At present, patients are
selected for prostate biopsy on the basis of age, serum prostate specific antigen (PSA), and …

The role of biomarkers in the assessment of prostate cancer risk prior to prostate biopsy: Which markers matter and how should they be used?

M Schmid, QD Trinh, M Graefen, M Fisch… - World journal of …, 2014 - Springer
Prostate cancer (PCa) screening has been substantially influenced by the clinical
implementation of serum prostate-specific antigen (PSA). In this context, improvement of …

Biomarkers for prostate biopsy and risk stratification of patients with newly diagnosed prostate cancer

S Loeb - Urology practice, 2017 - Elsevier
Introduction Many new markers are now available as an aid for decisions about prostate
biopsy for men without prostate cancer and/or to improve risk stratification for men with …

Predicting the outcome of prostate biopsy: comparison of a novel logistic regression‐based model, the prostate cancer risk calculator, and prostate‐specific antigen …

DJ Hernandez, M Han, EB Humphreys… - BJU …, 2009 - Wiley Online Library
OBJECTIVES To develop a logistic regression‐based model to predict prostate cancer
biopsy at, and compare its performance to the risk calculator developed by the Prostate …

Incorporating biomarkers into the primary prostate biopsy setting: a cost-effectiveness analysis

NJ Sathianathen, KM Kuntz, F Alarid-Escudero… - Journal of …, 2018 - journals.lww.com
Purpose: We performed a cost-effectiveness analysis using the PHI (Prostate Health Index),
4Kscore®, SelectMDx™ and the EPI (ExoDx™ Prostate [IntelliScore]) in men with elevated …

[HTML][HTML] Predicting prostate biopsy results using a panel of plasma and urine biomarkers combined in a scoring system

M Albitar, W Ma, L Lund, F Albitar, K Diep… - Journal of …, 2016 - ncbi.nlm.nih.gov
Background: Determining the need for prostate biopsy is frequently difficult and more
objective criteria are needed to predict the presence of high grade prostate cancer (PCa). To …

Development and validation of a novel multivariate risk score to guide biopsy decision for the diagnosis of clinically significant prostate cancer

H Klocker, B Golding, S Weber, E Steiner… - BJUI …, 2020 - Wiley Online Library
Objectives Selecting patients suspected of having prostate cancer (PCa) for a prostate
biopsy remains a challenge. Prostate‐specific antigen (PSA)‐based testing is hampered by …

[HTML][HTML] Risk calculators and updated tools to select and plan a repeat biopsy for prostate cancer detection

I Sorokin, BM Mian - Asian Journal of Andrology, 2015 - journals.lww.com
Millions of men each year are faced with a clinical suspicion of prostate cancer (PCa) but the
prostate biopsy fails to detect the disease. For the urologists, how to select the appropriate …

[HTML][HTML] Biomarkers for detection of clinically significant prostate cancer: contemporary clinical data and future directions

NW Eyrich, TM Morgan, JJ Tosoian - Translational Andrology and …, 2021 - ncbi.nlm.nih.gov
Use of serum prostate-specific antigen (PSA) testing for early detection of prostate cancer
appears to reduce cancer-specific mortality. Due to the limited specificity of PSA for clinically …