Grapefruit juice has been reported to markedly improve the bioavailability of triazolam,
midazolam, terfenadine, cyclosporine and several dihydropyridine calcium channel blockers …

Natural foods and vegetal supplements have recently become increasingly popular for their
roles in medicine and as staple foods. This has, however, led to the increased risk of …

Purpose. The aim of this study is to investigate the effects of 50% ethyl acetate extracts of
grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) …

Grapefruit juice (GFJ) is known to affect the bioavailability of drugs in different ways. Despite
the influence on gastrointestinal enzymes and transporters, the influence on gastrointestinal …

In this study, standardized food extracts were screened for their possible inhibitory effect on
the P‐glycoprotein (P‐gp)‐mediated efflux of 3H‐ciclosporin A (CsA) using the in‐vitro Caco …

Grapefruit juice is well documented to cause clinically significant increases in the plasma
concentrations of many therapeutic agents. These interactions are believed to be mediated …

Although it is well known and identifi ed that drug-drug interactions exist, the recognition of
importance of food and drug interactions to practice has been growing much slower. On the …

Background and Objectives Acute ingestion of usual quantities of grapefruit juice produces
inhibition of enteric cytochrome P450 (CYP) 3A enzymes, causing pharmacokinetic …

The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied
in vitro and in healthy human volunteers. In human liver microsomes, the mean 50 …

Grapefruit juice alters the concentrations of many CYP3A substrates. The objective of this
study was to examine the effect of grapefruit juice on the pharmacokinetics and …