[HTML][HTML] Biomaterials for nanoparticle vaccine delivery systems

P Sahdev, LJ Ochyl, JJ Moon - Pharmaceutical research, 2014 - Springer
Subunit vaccination benefits from improved safety over attenuated or inactivated vaccines,
but their limited capability to elicit long-lasting, concerted cellular and humoral immune …

Triggered nanoparticles as therapeutics

CS Kim, B Duncan, B Creran, VM Rotello - Nano today, 2013 - Elsevier
Drug delivery systems (DDSs) face several challenges including site-specific delivery,
stability, and the programmed release of drugs. Engineered nanoparticle (NP) surfaces with …

Macrophage-targeted delivery systems for nucleic acid therapy of inflammatory diseases

A Singh, M Talekar, A Raikar, M Amiji - Journal of controlled release, 2014 - Elsevier
Inflammation is an immune response that marks several pathophysiological conditions in
our body. Though adaptive immune cells play a major role in the progression of the disease …

Microneedles for painless transdermal immunotherapeutic applications

H Amani, MA Shahbazi, C D'Amico, F Fontana… - Journal of Controlled …, 2021 - Elsevier
Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in
the treatment of various diseases. However, owing to the dynamic nature of the immune …

Intradermal delivery for vaccine dose sparing: overview of current issues

D Zehrung, C Jarrahian, A Wales - Vaccine, 2013 - Elsevier
There is a wide range of methods and technologies aimed at improving human vaccine
products and the way they are delivered. Some of these have the potential to increase …

Modulation of immune responses using adjuvants to facilitate therapeutic vaccination

V Schijns, A Fernández‐Tejada… - Immunological …, 2020 - Wiley Online Library
Therapeutic vaccination offers great promise as an intervention for a diversity of infectious
and non‐infectious conditions. Given that most chronic health conditions are thought to have …

Flexible macromolecule versus rigid particle retention in the injected skin and accumulation in draining lymph nodes are differentially influenced by hydrodynamic size

NA Rohner, SN Thomas - ACS biomaterials science & engineering, 2017 - ACS Publications
Therapeutic immunomodulation in the skin, its draining lymph nodes, or both tissues
simultaneously using an intradermal administration scheme is desirable for a variety of …

[HTML][HTML] Hitchhiking on controlled-release drug delivery systems: opportunities and challenges for cancer vaccines

L Han, K Peng, LY Qiu, M Li, JH Ruan, LL He… - Frontiers in …, 2021 - frontiersin.org
Cancer vaccines represent among the most promising strategies in the battle against
cancers. However, the clinical efficacy of current cancer vaccines is largely limited by the …

[HTML][HTML] Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

BR Burton, GJ Britton, H Fang, J Verhagen… - Nature …, 2014 - nature.com
Antigen-specific immunotherapy combats autoimmunity or allergy by reinstating
immunological tolerance to target antigens without compromising immune function …

Drug nanocarriers to treat autoimmunity and chronic inflammatory diseases

D Prosperi, M Colombo, I Zanoni, F Granucci - Seminars in immunology, 2017 - Elsevier
Nanoparticles represent a new generation of drug delivery systems that can be engineered
to harness optimal target selectivity for specific cells and tissues and high drug loading …