Highlights•Trained immunity reprograms innate immune responses in humans.•Trained
immunity plays a role in the pathophysiology of immune-mediated diseases.•Targeting …

The immune system is the key target for vaccines and immunotherapeutic approaches
aimed at blunting infectious diseases, cancer, autoimmunity, and implant rejection …

Although a great public heath success, vaccines provide suboptimal protection in some
patient populations and are not available to protect against many infectious diseases …

Cell therapies enable unprecedented treatment options to replace tissues, destroy tumors
and facilitate regeneration. The greatest challenge facing cell therapy is the inability to …

Drug delivery has made tremendous advances in the last decade. Targeted therapies are
increasingly common, with intracellular delivery highly impactful and sought after …

Despite two centuries of vaccine use, only a few adjuvants and delivery systems are
licensed for human use. This is partly because traditional vaccines based on attenuated live …

Researchers working on the development of vaccines face an inherent dilemma: to
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …

Advances in the understanding of the pathogenesis of infectious diseases and cancer
immunology have inspired many new approaches to vaccine development. Many subunit …

Recent advances in controlled delivery systems for protein pharmaceuticals such as
microspheres, liposomes, pumps and implants, have provided a new avenue for delivery of …

Activating the immune system to trigger a specific response is a major challenge in vaccine
development. In particular, activating sufficient cytotoxic T lymphocyte-mediated cellular …