Alternative methods of vaccine delivery: an overview of edible and intradermal vaccines

E Criscuolo, V Caputo, RA Diotti… - Journal of …, 2019 - Wiley Online Library
Vaccines are recognized worldwide as one of the most important tools for combating
infectious diseases. Despite the tremendous value conferred by currently available vaccines …

Crossing the barrier: Targeting epithelial receptors for enhanced oral vaccine delivery

B Devriendt, BG De Geest, BM Goddeeris… - Journal of controlled …, 2012 - Elsevier
Vaccination is the most efficient way to combat and prevent infectious diseases. However,
most vaccines are administered systemically and are ineffective in eliciting protective …

Intradermal delivery of vaccine nanoparticles using hollow microneedle array generates enhanced and balanced immune response

L Niu, LY Chu, SA Burton, KJ Hansen… - Journal of controlled …, 2019 - Elsevier
Hollow microneedles can help overcome the skin permeation barrier imposed by the stratum
corneum and facilitate transcutaneous delivery of nanoparticle delivery systems. In the …

Microparticle-based technologies for vaccines

DT O'Hagan, M Singh, JB Ulmer - Methods, 2006 - Elsevier
Microparticles have been effectively used for many years as delivery systems for drugs and
therapeutic proteins. Their application to the delivery of vaccines is not as extensive, but is …

Designing polymeric particles for antigen delivery

S De Koker, BN Lambrecht, MA Willart… - Chemical Society …, 2011 - pubs.rsc.org
By targeting dendritic cells, polymeric carriers in the nano to lower micron range constitute
very interesting tools for antigen delivery. In this critical review, we review how new …

Macrophage cell membrane‐cloaked nanoplatforms for biomedical applications

J Lopes, D Lopes, M Pereira‐Silva, D Peixoto… - Small …, 2022 - Wiley Online Library
Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage
nanoparticles to circumvent some limitations of nanoscale materials. This emergent cell …

Immunomodulating activities of soluble synthetic polymer-bound drugs

B Řı́hová - Advanced drug delivery reviews, 2002 - Elsevier
The introduction of a synthetic material into the body always affects different body systems,
including the defense system. Synthetic polymers are usually thymus-independent antigens …

Single-injecting, bioinspired nanocomposite hydrogel that can recruit host immune cells in situ to elicit potent and long-lasting humoral immune responses

C Korupalli, WY Pan, CY Yeh, PM Chen, FL Mi… - Biomaterials, 2019 - Elsevier
Vaccination is an effective medical intervention for preventing disease. However, without an
adjuvant, most subunit vaccines are poorly immunogenic. This work develops a bioinspired …

Controlled delivery of peptides and proteins

I Tuncer Degim, N Celebi - Current pharmaceutical design, 2007 - ingentaconnect.com
The final aim/target of Pharmaceutical Sciences is to design successful dosage forms for
effective therapy, considering individual patient needs and compliance. Development of new …

Nanoparticle-based drug delivery systems for induction of tolerance and treatment of autoimmune diseases

H Li, YG Yang, T Sun - Frontiers in bioengineering and biotechnology, 2022 - frontiersin.org
Autoimmune disease is a chronic inflammatory disease caused by disorders of immune
regulation. Antigen-specific immunotherapy has the potential to inhibit the autoreactivity of …