In this Special Issue (SI), with a theme of “Integrative Genomics and Systems Medicine in
Cancer”, we have collected a total of 12 research and review articles from researchers in the …

Cancer has been a paradigmatic example of a complex disease. It is the second leading
cause of death worldwide. Knowledge acquired on the mechanisms and potential causes …

It is becoming evident that holistic perspectives toward cancer are crucial in deciphering the
overwhelming complexity of tumors. Single-layer analysis of genome-wide data has greatly …

With over two hundred types of cancer diagnosed to date, researchers the world over have
been forced to rapidly update their understanding of the biology of cancer. In fact, only the …

Current and emerging biomedical science efforts are driven by determining how to improve
clinical outcomes for patients, but the roadmap to achieve this goal has been controversial …

Synergistically integrating multi-layer genomic data at systems level not only can lead to
deeper insights into the molecular mechanisms related to disease initiation and progression …

Cancer is a complex disease involving multiple mechanisms and critical players, at broad
genomic, transcriptional, translational and/or biochemical levels. One could envision …

Cancer is a leading cause of death worldwide, claiming millions of lives each year. Cancer
biology is an essential research field to understand how cancer develops, evolves, and …

Recent studies of the human genome have indicated that regulatory elements (eg promoters
and enhancers) at distal genomic locations can interact with each other via chromatin …

Cancers are complex heterogeneous diseases characterized by the unconditional and
abnormal division of eukaryotic cells. When cell division remains unchecked within the body …