All of the members of this family are thought to facilitate zinc efflux from the cytoplasm either
into various intracellular compartments (endosomes, secretory granules, synaptic vesicles …

Zinc is an essential micronutrient, so it is important to elucidate the molecular mechanisms of
zinc homeostasis, including the functional properties of zinc transporters. Mammalian zinc …

Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …

The solute carriers families 30 (SLC30; ZnT), 39 (SLC39; ZIP), and 31 (SLC31; CTR) are
involved in the essential maintenance of cellular zinc (Zn 2+) and copper (Cu 2+) …

Maintenance of cellular zinc homeostasis includes regulating the expression of cell
membrane zinc transporters. Knowledge about the mechanisms underlying changes in …

▪ Abstract New insights into mammalian zinc metabolism have been acquired through the
identification and characterization of zinc transporters. These proteins all have …

ZnT7, a novel member of the zinc transporter (ZnT) family, was identified by searching the
expressed sequence tag (EST) databases with the amino acid sequence of ZnT1. Like the …

We describe ZnT6, a new member of the CDF (cation diffusion facilitator) family of heavy
metal transporters. The humanZNT6 gene was mapped at 2p21–22, while the mouseZnt6 …

The SLC30 family of cation diffusion transporters includes at least nine members in
mammals, most of which have been documented to play a role in zinc transport. The …

Intracellular homeostasis for zinc is achieved through the coordinate regulation of specific
transporters engaged in zinc influx, efflux, and intracellular compartmentalization. We have …