Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers
RD Palmiter, L Huang - Pflügers Archiv, 2004 - Springer
All of the members of this family are thought to facilitate zinc efflux from the cytoplasm either
into various intracellular compartments (endosomes, secretory granules, synaptic vesicles …
into various intracellular compartments (endosomes, secretory granules, synaptic vesicles …
ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells
RA Valentine, KA Jackson, GR Christie… - Journal of biological …, 2007 - ASBMB
Zinc is an essential micronutrient, so it is important to elucidate the molecular mechanisms of
zinc homeostasis, including the functional properties of zinc transporters. Mammalian zinc …
zinc homeostasis, including the functional properties of zinc transporters. Mammalian zinc …
The SLC30 family of zinc transporters–a review of current understanding of their biological and pathophysiological roles
L Huang, S Tepaamorndech - Molecular aspects of medicine, 2013 - Elsevier
Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …
The families of zinc (SLC30 and SLC39) and copper (SLC31) transporters
M Schweigel-Röntgen - Current topics in membranes, 2014 - Elsevier
The solute carriers families 30 (SLC30; ZnT), 39 (SLC39; ZIP), and 31 (SLC31; CTR) are
involved in the essential maintenance of cellular zinc (Zn 2+) and copper (Cu 2+) …
involved in the essential maintenance of cellular zinc (Zn 2+) and copper (Cu 2+) …
Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localized and regulated by zinc through transcription and mRNA stability
KA Jackson, RM Helston, JA McKay, ED O'Neill… - Journal of Biological …, 2007 - ASBMB
Maintenance of cellular zinc homeostasis includes regulating the expression of cell
membrane zinc transporters. Knowledge about the mechanisms underlying changes in …
membrane zinc transporters. Knowledge about the mechanisms underlying changes in …
Mammalian zinc transporters
JP Liuzzi, RJ Cousins - Annu. Rev. Nutr., 2004 - annualreviews.org
▪ Abstract New insights into mammalian zinc metabolism have been acquired through the
identification and characterization of zinc transporters. These proteins all have …
identification and characterization of zinc transporters. These proteins all have …
ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus
CP Kirschke, L Huang - Journal of Biological Chemistry, 2003 - ASBMB
ZnT7, a novel member of the zinc transporter (ZnT) family, was identified by searching the
expressed sequence tag (EST) databases with the amino acid sequence of ZnT1. Like the …
expressed sequence tag (EST) databases with the amino acid sequence of ZnT1. Like the …
Functional characterization of a novel mammalian zinc transporter, ZnT6
L Huang, CP Kirschke, J Gitschier - Journal of biological chemistry, 2002 - ASBMB
We describe ZnT6, a new member of the CDF (cation diffusion facilitator) family of heavy
metal transporters. The humanZNT6 gene was mapped at 2p21–22, while the mouseZnt6 …
metal transporters. The humanZNT6 gene was mapped at 2p21–22, while the mouseZnt6 …
Mouse zinc transporter 1 gene provides an essential function during early embryonic development
GK Andrews, H Wang, SK Dey, RD Palmiter - genesis, 2004 - Wiley Online Library
The SLC30 family of cation diffusion transporters includes at least nine members in
mammals, most of which have been documented to play a role in zinc transport. The …
mammals, most of which have been documented to play a role in zinc transport. The …
Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic β cells
T Kambe, H Narita, Y Yamaguchi-Iwai, J Hirose… - Journal of Biological …, 2002 - ASBMB
Intracellular homeostasis for zinc is achieved through the coordinate regulation of specific
transporters engaged in zinc influx, efflux, and intracellular compartmentalization. We have …
transporters engaged in zinc influx, efflux, and intracellular compartmentalization. We have …