Signaling pathways consist of a chain of biochemical events that form the intracellular
equivalent of a fire bucket brigade. An initial change or chemical signal outside the cell is …

Characterization of the interactions between soluble factors required for nuclear transport is
key to understanding the process of nuclear trafficking. Using a synthetic lethal screen with …

RNA-binding proteins are involved in various aspects of RNA metabolism such as
processing, translational control, stabilization, localization and transport. Many of these …

Three independent pathways of nuclear import have so far been identified in yeast, each
mediated by cognate nuclear transport factors, or karyopherins. Here we have characterized …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Studies over the past 10 years have provided major insights into the molecular mechanisms
responsible for active transport of macromolecules in and out of the nucleus …

Following transcription and processing, eukaryotic mRNAs are exported from the nucleus to
the cytoplasm for translation. Here we present evidence that mRNAs are targeted for nuclear …

In eukaryotic cells, cell functions are maintained in an orderly manner through the
continuous traffic of various proteins between the cell nucleus and the cytoplasm. The …

Export of mRNA through nuclear pore complexes (NPC) is preceded by multiple and well
coordinated processing steps, resulting in the formation of an export competent …

The nucleus of eukaryotic cells contains a distinct set of proteins necessary for the
management of genes. Following synthesis in the cytoplasm, proteins enter the nucleus …