Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

Q Wang, ZN Shen, SJ Zhang, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Neurological diseases impose a tremendous and increasing burden on global health, and
there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried …

Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway

Q Zhang, M Yao, J Qi, R Song, L Wang, J Li… - Frontiers in …, 2023 - frontiersin.org
Introduction: Puerarin (PUE) is a natural compound isolated from Puerariae Lobatae Radix,
which has a neuroprotective effect on IS. We explored the therapeutic effect and underlying …

[HTML][HTML] Puerarin: a potential natural neuroprotective agent for neurological disorders

X Liu, R Huang, J Wan - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese
medicine. Accumulating evidence has indicated that puerarin demonstrates multiple …

Puerarin prevents tumor necrosis factor-α-induced apoptosis of PC12 cells via activation of the PI3K/Akt signaling pathway

F Liang, S Xie - Experimental and Therapeutic …, 2017 - spandidos-publications.com
Tumor necrosis factor-α (TNF-α), a potential proinflammatory cytokine, is an important
component involved in neuronal apoptosis associated with neuroinflammation in the central …

[HTML][HTML] Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K/Akt1/GSK-3β signaling pathway in an in vivo …

J Tao, Y Cui, Y Duan, N Zhang, C Wang, F Zhang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Ischemic stroke causes irreversible damage to the brain. The hippocampus is a vulnerable
region and plays an important role in cognition and locomotor activity. Puerarin is a …

[HTML][HTML] Neuroprotective mechanisms of puerarin in central nervous system diseases: Update

CC Yu, YJ Du, J Li, Y Li, L Wang, LH Kong… - Aging and …, 2022 - ncbi.nlm.nih.gov
Due to global population aging and modern lifestyle changes, the incidence of central
nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric …

Puerarin protects against β-amyloid-induced microglia apoptosis via a PI3K-dependent signaling pathway

C Wang, N Xie, H Zhang, Y Li, Y Wang - Neurochemical research, 2014 - Springer
Puerarin extracted from Radix puerariae is well-known for its anti-oxidative and
neuroprotective activities. In this study, we investigated the protective effect of puerarin on …

[HTML][HTML] The neuroprotective effect of puerarin in acute spinal cord injury rats

D Zhang, G Ma, M Hou, T Zhang, L Chen… - Cellular Physiology and …, 2016 - karger.com
Background: Acute spinal cord injury (SCI) leads to permanent disabilities. This study
evaluated the neuroprotective effect of puerarin, a natural extract, in a rat model of SCI …

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway

JF Wang, ZG Mei, Y Fu, SB Yang… - Neural regeneration …, 2018 - journals.lww.com
Puerarin suppresses autophagy to alleviate cerebral ischemia/reperfusion injury, and
accumulating evidence indicates that the AMPK-mTOR signaling pathway regulates the …

Neuroprotective effects of puerarin on 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine induced Parkinson's disease model in mice

G Zhu, X Wang, S Wu, X Li, Q Li - Phytotherapy Research, 2014 - Wiley Online Library
Puerarin, an active component of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep
is well‐known for its anti‐oxidative and neuroprotective activities. Although anti‐Parkinson's …