The biology of obesity

P Trayhurn - Proceedings of the Nutrition Society, 2005 - cambridge.org
Obesity is a multidisciplinary area, the 'biology'of which encompasses:(1) the fundamental
mechanisms of energy balance and its regulation;(2) the biological basis for the …

Adipose tissue in obesity—an inflammatory issue

P Trayhurn - Endocrinology, 2005 - academic.oup.com
White adipose tissue (WAT), long regarded as a “Cinderella organ,” has truly emerged into
the limelight, and much of the stimulus for this relates to the current concern with obesity …

Adipokines: inflammation and the pleiotropic role of white adipose tissue

P Trayhurn, IS Wood - British journal of nutrition, 2004 - cambridge.org
White adipose tissue is now recognised to be a multifunctional organ; in addition to the
central role of lipid storage, it has a major endocrine function secreting several hormones …

Endocrine and signalling role of adipose tissue: new perspectives on fat

P Trayhurn - Acta Physiologica Scandinavica, 2005 - Wiley Online Library
White adipose tissue (WAT) is now recognized as a major endocrine and secretory organ,
releasing a wide range of protein factors and signals termed adipokines–in addition to fatty …

Adrenoceptors, uncoupling proteins, and energy expenditure

S Collins, W Cao, KW Daniel… - Experimental …, 2001 - journals.sagepub.com
Interest in the biology of adipose tissue has undergone a revival in recent years with the
discovery of a host of genes that contribute to the regulation of satiety and metabolic rate …

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

P Trayhurn, JH Beattie - Proceedings of the Nutrition Society, 2001 - cambridge.org
The traditional role attributed to white adipose tissue is energy storage, fatty acids being
released when fuel is required. The metabolic role of white fat is, however, complex. For …

Signalling role of adipose tissue: adipokines and inflammation in obesity

P Trayhurn, IS Wood - Biochemical Society Transactions, 2005 - portlandpress.com
White adipose tissue (WAT) is a major endocrine and secretory organ, which releases a
wide range of protein signals and factors termed adipokines. A number of adipokines …

The human uncoupling protein‐1 gene (UCP1): present status and perspectives in obesity research

MDM Gonzalez‐Barroso, D Ricquier… - Obesity …, 2000 - Wiley Online Library
Energy expenditure through brown adipose tissue thermogenesis contributes either to
maintenance of body temperature in a cold environment or to wasted food energy, ie cold …

[HTML][HTML] Adipose tissue and adipokines—energy regulation from the human perspective

P Trayhurn, C Bing, IS Wood - The Journal of nutrition, 2006 - Elsevier
There has been a rapid rise in the incidence of obesity, primarily as a result of changes in
lifestyle (diet and activity levels). Obesity has provided considerable impetus for the …

Genomic organization and mutational analysis of the human UCP2 gene, a prime candidate gene for human obesity

KU Lentes, N Tu, H Chen, U Winnikes… - Journal of Receptors …, 1999 - Taylor & Francis
Uncoupling proteins (UCPs) are mitochondrial membrane transporters which are involved in
dissipating the proton electrochemical gradient thereby releasing stored energy as heat …