Immune dysfunction is commonly associated with several neurological and mental
disorders. Although the mechanisms by which peripheral immunity may influence neuronal …

The mechanisms of communication between the brain and the immune cells are still largely
unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate …

The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …

Recent studies suggested that microglia, the primary brain immune cells, can affect circuit
connectivity and neuronal function,. Microglia infiltrate the neuroepithelium early in …

Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in
response to environmental stimuli and alters subsequent immune responses. Two types of …

Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …

It has been speculated that brain activities might directly control adaptive immune responses
in lymphoid organs, although there is little evidence for this. Here we show that splenic …

Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …

Multiple sclerosis (MS) patients exhibit neuropsychological symptoms in early disease
despite the immune attack occurring predominantly in white matter and spinal cord. It is …