Role of the Salmonella enterica serovar Typhi Fur regulator and small RNAs RfrA and RfrB in iron homeostasis and interaction with host cells

JM Leclerc, CM Dozois, F Daigle - Microbiology, 2013 - microbiologyresearch.org
Iron is an essential element but can be toxic at high concentrations. Therefore, its acquisition
and storage require tight control. Salmonella encodes the global regulator Fur (ferric uptake …

Control of Fur synthesis by the non‐coding RNA RyhB and iron‐responsive decoding

B Večerek, I Moll, U Bläsi - The EMBO journal, 2007 - embopress.org
The Fe2+‐dependent Fur protein serves as a negative regulator of iron uptake in bacteria.
As only metallo‐Fur acts as an autogeneous repressor, Fe2+ scarcity would direct fur …

Interplay between iron homeostasis and virulence: Fur and RyhB as major regulators of bacterial pathogenicity

G Porcheron, CM Dozois - Veterinary microbiology, 2015 - Elsevier
In bacteria–host interactions, competition for iron is critical for the outcome of the infection.
As a result of its redox properties, this metal is essential for the growth and proliferation of …

Induction of the ferritin gene (ftnA) of Escherichia coli by Fe2+–Fur is mediated by reversal of H‐NS silencing and is RyhB independent

A Nandal, CCO Huggins, MR Woodhall… - Molecular …, 2010 - Wiley Online Library
FtnA is the major iron‐storage protein of Escherichia coli accounting for≤ 50% of total
cellular iron. The FtnA gene (ftnA) is induced by iron in an Fe2+–Fur‐dependent fashion …

Regulation of iron transport systems in Enterobacteriaceae in response to oxygen and iron availability

C Carpenter, SM Payne - Journal of inorganic biochemistry, 2014 - Elsevier
Iron is an essential nutrient for most bacteria. Depending on the oxygen available in the
surrounding environment, iron is found in two distinct forms: ferrous (Fe II) or ferric (Fe III) …

Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis

PJ Wilderman, NA Sowa… - Proceedings of the …, 2004 - National Acad Sciences
In many bacteria, iron homeostasis is controlled primarily by the ferric uptake regulator (Fur),
a transcriptional repressor. However, some genes, including those involved in iron storage …

Avoidance of iron toxicity through regulation of bacterial iron transport.

V Braun - Biological chemistry, 1997 - europepmc.org
Under oxic conditions and at pH 7, ferric iron is insoluble, and complex formation of Fe3+
with ligands is required to supply cells with iron. Bacteria and fungi synthesize and secrete …

Feo–transport of ferrous iron into bacteria

ML Cartron, S Maddocks, P Gillingham, CJ Craven… - Biometals, 2006 - Springer
Bacteria commonly utilise a unique type of transporter, called Feo, to specifically acquire the
ferrous (Fe 2+) form of iron from their environment. Enterobacterial Feo systems are …

Regulation by iron: RNA rules the rust

RJ Kadner - Journal of bacteriology, 2005 - Am Soc Microbiol
Obtaining and maintaining proper levels of iron are major challenges for most organisms
(reviews may be found in references 2, 9, and 10). The redox features that make iron such a …

Heme uptake and utilization by gram-negative bacterial pathogens

KL Richard, BR Kelley, JG Johnson - Frontiers in cellular and …, 2019 - frontiersin.org
Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …