In the gammaproteobacteria, the FeoA, FeoB, and FeoC proteins constitute the Feo system,
which mediates ferrous iron [Fe (II)] import. Of these Feo proteins, FeoB is an inner …

Intracellular iron homeostasis in bacteria is primarily regulated by ferric uptake regulator
(Fur). Since its discovery, Fur has been assumed to bind ferrous iron and regulate …

Iron is limiting in the human host, and bacterial pathogens respond to this environment by
activating genes required for bacterial virulence. Transcriptional regulation in response to …

Iron is essential for Escherichia coli growth and survival in the host and the external
environment, but its availability is generally low due to the poor solubility of its ferric form in …

Iron-sulfur (Fe-S) clusters are fundamental to numerous biological processes in most
organisms, but these protein cofactors can be prone to damage by various oxidants (eg, O2 …

To maintain iron homeostasis within the cell, bacteria have evolved various types of iron
acquisition systems. Ferric iron (Fe3+) is the dominant species in an oxygenated …

Reactive oxygen species are generated by redox reactions and the Fenton reaction of H2O2
and iron that generates the hydroxyl radical that causes severe DNA, protein, and lipid …

Short-range DNA looping has been proposed to affect promoter activity in many bacterial
species and operator configurations, but only few examples have been experimentally …

Bacterial cells modulate transcription in response to changes in iron availability. The ferric
uptake regulator (Fur) senses intracellular iron availability and plays a central role in …

Iron is the most abundant transition metal in the human body and its bioavailability is
stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to …