In this study, we investigated the effect of the xanthine oxidase (XO) inhibitor, allopurinol
(ALP), on cardiac dysfunction, oxidative‐nitrosative stress, apoptosis, poly (ADP‐ribose) …

Allopurinol (ALP) attenuates oxidative stress and diabetic cardiomyopathy (DCM), but the
mechanism is unclear. Activation of nuclear factor erythroid 2‐related factor 2 (Nrf2) …

Background Xanthine oxidase‐derived superoxide production and oxidative stress
contribute to the development of diabetic complications including diabetic cardiomyopathy …

Diabetic cardiomyopathy is a major and severe cardiovascular complication of diabetes
mellitus. Ursolic acid, a pentacyclic triterpene compound widespread in fruits and plants …

Background We have previously shown that hyperuricemia plays an important role in the
vascular complications of insulin resistance (IR). Here we investigated the effect of xanthine …

Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

Diabetic cardiomyopathy is one of the major mortality risk factors among diabetic patients
worldwide. It has been established that most of the cardiac structural and functional …

We evaluated the preventive effect of allopurinol on isoproterenol (ISO) induced myocardial
infarction in aged rats. Twelve‐to fourteen‐month‐old male Long Evans rats were divided …

Diabetes mellitus is one of the most common chronic diseases affecting millions of people
worldwide. Cardiovascular complication including myocardial infarction is one of the major …

Background Diabetic cardiomyopathy (DCM) is a nonischemic myocardial disorder
characterized by metabolic disturbances and oxidative stress in diabetic patients. The …