Despite the documented efficacy of cardiac glycosides in improving symptoms in patients
with heart failure caused by systolic ventricular dysfunction, considerable debate continues …

Summary 1 Cardiac glycosides have been used for centuries as therapeutic agents for the
treatment of heart diaseases. In patients with heart failure, digoxin and the other glycosides …

Although it has been known for more than a century that digitalis glycosides exert a powerful
beneficial effect on patients with heart failure, atrial fibrillation and a rapid ventricular rate, it …

Clinical Use of Digitalis Glycosides The potential benefit of digoxin therapy in heart failure
patients is thought to be related to its positive inotropic effect that increases cardiac output …

Congestive Heart Failure The prime indication for digitalis therapy is congestive heart failure
resulting from defec-tive mnyocardial contraction or from the in-efficiency of excessive …

SOME preparation of the fox glove plant (digitalis purpurea) has had a place in domestic
and medical therapy for centuries. It was however a Birmingham physician, Withering, 18 …

The mechanisms by which digitalis causes its therapeutic and toxic actions have been
studied for nearly a half century, revealing a great deal about cardiac cell regulation of …

A DECADE has passed since the clinical use of cardiac glycosides was last reviewed in
these pages. 1 Despite continuing uncertainty regarding fundamental mechanisms of action …

Congestive heart failure (CHF) occurs when the ventricle is unable to provide an adequate
cardiac output to meet the metabolic demands of the body1 and is characterized by …

Despite recent advances in understanding of the pharmacokinetics and electrophysiologic
effects of cardiac glycosides, digitalis toxicity remains distressingly common in clinical …