Extracellular vesicles have been described in non-paracrine cellular interactions in cancer.
We report a similar phenomenon in B-cell precursor (BCP) acute lymphoblastic leukaemia …

Patient-derived xenografted (PDX) models were generated through the transplantation of
primary acute lymphoblastic leukemia (ALL) cells into immunodeficient NSG mice. We …

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles 30 to 1000 nm in size
and represent a novel mechanism of cell communication. By transferring RNA and protein …

Simple Summary Extracellular vesicles (EVs) are lipid bound vesicles secreted by cells into
the extracellular space. They play an important role in cell-to-cell communication by …

Cancer cells produce unique heterogeneous vesicles1 capable of transferring oncogenic
material2, 3 to other cells, 4, 5 with the potential of modulating a tumor-supportive …

Acute myeloid leukemia (AML) cells can secrete trophic factors, including extracellular
vesicles (EVs), instructing the stromal leukemic niche. Here, we introduce a scalable …

Simple Summary Chronic lymphocytic leukemia (CLL) is characterized by the accumulation
of abnormal B lymphocytes in the peripheral components of the immune system. Despite the …

Following their discovery at the end of the 20th century, extracellular vesicles (EVs) ranging
from 50-1,000 nm have proven to be paramount in the progression of many cancers …

Extracellular vesicles (EV) are nano-sized membrane enclosed vehicles that are involved in
cell-to-cell communication and carry cargo that is representative of the parent cell. Recent …

Exosomes derived from solid tumor cells are involved in immune suppression,
angiogenesis, and metastasis, but the role of leukemia-derived exosomes has been less …