Osteoarthritis is a complex degenerative joint disease. Here, we investigate matched
genotype and methylation profiles of primary chondrocytes from macroscopically intact (low …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Objectives To elucidate the functional epigenomic landscape of articular cartilage in
osteoarthritis (OA) affected knee and hip joints in relation to gene expression. Methods …

Osteoarthritis is the most prevalent whole-joint degenerative disorder, and is characterized
by the degradation of articular cartilage and the underlying bone structures. Almost 600 …

Objective Cartilage epigenetic changes are strongly associated with human osteoarthritis
(OA). However, the influence of individual environmental OA risk factors on these epigenetic …

Objective Osteoarthritis (OA) is polygenic with over 90 independent genome-wide
association loci so far reported. A key next step is the identification of target genes and the …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Osteoarthritis is a common, complex disease with no curative therapy. In this review, we
summarize current knowledge on disease aetiopathogenesis and outline genetics and …

The purpose of this narrative review is to provide an overview of last year's publications in
the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes …

Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …