Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA …
Abstract Treatment of patients with triple-negative breast cancer (TNBC) is challenging due
to the absence of well-defined molecular targets and the heterogeneity of such disease. In …
to the absence of well-defined molecular targets and the heterogeneity of such disease. In …
[PDF][PDF] Cell-specific cytotoxic effect of pyrazole derivatives on breast cancer cell lines MCF7 and MDA-MB-231
TP Lehmann, J Kujawski, J Kruk, K Czaja… - J Physiol …, 2017 - researchgate.net
Pyrazoles and their derivatives belong to a class of compounds that demonstrate a great
potential in design of anticancer, antiangiogenic, and antimetastatic drugs. Our earlier …
potential in design of anticancer, antiangiogenic, and antimetastatic drugs. Our earlier …
Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)] benzyl-phenylpyrrolo [1, 2-a] quinoxaline-carboxylate derivatives in …
V Desplat, M Vincenzi, R Lucas, S Moreau… - European Journal of …, 2016 - Elsevier
Leukemia is the most common blood cancer, and its development starts at diverse points,
leading to distinct subtypes that respond differently to therapy. This heterogeneity is rarely …
leading to distinct subtypes that respond differently to therapy. This heterogeneity is rarely …
Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF‐7 Cells
Two new synthesized and characterized quinazoline Schiff bases 1 and 2 were investigated
for anticancer activity against MCF‐7 human breast cancer cell line. Compounds 1 and 2 …
for anticancer activity against MCF‐7 human breast cancer cell line. Compounds 1 and 2 …
A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells
JA Marchal, MC Núñez, I Suárez… - Breast cancer research …, 2007 - Springer
The anticarcinogenic potential of (RS)-1-(2, 3-dihydro-5 H-1, 4-benzodioxepin-3-yl) uracil
(DBDU), with the naturally occurring pyrimidine base uracil, is reported against the MCF-7 …
(DBDU), with the naturally occurring pyrimidine base uracil, is reported against the MCF-7 …
[HTML][HTML] 2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells
MW Lin, JS Yang, CC Lu, C Lin, SC Kuo… - Oncology …, 2018 - spandidos-publications.com
The present study aimed to investigate the biological effects of the new compound 2‑phenyl‑
4‑quinolone (YT‑1) on human leukemia cells. Cell viability was determined by propidium …
4‑quinolone (YT‑1) on human leukemia cells. Cell viability was determined by propidium …
In vitro apoptotic mechanism of a novel synthetic Quinazolinyl derivative: induces caspase-dependent intrinsic pathway on THP-1, leukemia cell line
S Vakamullu, SK Arepalli, LR Velatooru… - Chemico-biological …, 2018 - Elsevier
Several quinazoline derivatives have been found to possess a broad spectrum of biological
activities. Previously our research group has synthesized and studied the anti-proliferative …
activities. Previously our research group has synthesized and studied the anti-proliferative …
Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells
EM Perchellet, MM Ward, AL Skaltsounis… - Anticancer …, 2006 - ar.iiarjournals.org
Background: Synthetic pyranoxanthenones, pyranothioxanthenones and their pyrazole-
fused derivatives, which bind to DNA, block the G 2+ M-phases of the cell cycle and inhibit …
fused derivatives, which bind to DNA, block the G 2+ M-phases of the cell cycle and inhibit …
[HTML][HTML] Anticancer Properties of 3-Dietoxyphosphorylfuroquinoline-4, 9-dione
J Drogosz-Stachowicz, K Gach-Janczak, M Mirowski… - Molecules, 2023 - mdpi.com
Herein, the antitumor activity of a novel synthetic analog with 5, 8-quinolinedione scaffold,
diethyl (2-(2-chlorophenyl)-4, 9-dioxo-4, 9-dihydrofuro [3, 2-g] quinolin-3-yl) phosphonate …
diethyl (2-(2-chlorophenyl)-4, 9-dioxo-4, 9-dihydrofuro [3, 2-g] quinolin-3-yl) phosphonate …
Design, synthesis and antitumour evaluation of novel anthraquinone derivatives
KW Lin, WH Lin, CL Su, HY Hsu, CN Lin - Bioorganic Chemistry, 2021 - Elsevier
We report the design, synthesis, and biological evaluation of 13 new and 1 known
anthraquinone derivatives which exerted cytotoxicity against PC3, A549 and NTUB1 cell …
anthraquinone derivatives which exerted cytotoxicity against PC3, A549 and NTUB1 cell …