[HTML][HTML] The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT …
A Gornowicz, A Szymanowska, M Mojzych… - International Journal of …, 2020 - mdpi.com
The discovery of cytotoxic drugs is focused on designing a compound structure that directly
affects cancer cells without an impact on normal cells. The mechanism of anticancer activity …
affects cancer cells without an impact on normal cells. The mechanism of anticancer activity …
Design, synthesis and antitumour evaluation of novel anthraquinone derivatives
KW Lin, WH Lin, CL Su, HY Hsu, CN Lin - Bioorganic Chemistry, 2021 - Elsevier
We report the design, synthesis, and biological evaluation of 13 new and 1 known
anthraquinone derivatives which exerted cytotoxicity against PC3, A549 and NTUB1 cell …
anthraquinone derivatives which exerted cytotoxicity against PC3, A549 and NTUB1 cell …
Pyrrolo-quinoline derivatives as potential antineoplastic drugs
MG Ferlin, B Gatto, G Chiarelotto, M Palumbo - Bioorganic & medicinal …, 2000 - Elsevier
Some novel pyrrolo-quinoline derivatives have been synthesized as potential antineoplastic
agents. They contain an angular aromatic tricyclic or tetracyclic system, to which the …
agents. They contain an angular aromatic tricyclic or tetracyclic system, to which the …
Novel [l,2,4]triazolo[3,4-a]isoquinoline chalcones as new chemotherapeutic agents: Block IAP tyrosine kinase domain and induce both intrinsic and extrinsic …
Two novel chemotherapeutic chalcones were synthesized and their structures were
confirmed by different spectral tools. Theoretical studies such as molecular modeling were …
confirmed by different spectral tools. Theoretical studies such as molecular modeling were …
Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells
EM Perchellet, MM Ward, AL Skaltsounis… - Anticancer …, 2006 - ar.iiarjournals.org
Background: Synthetic pyranoxanthenones, pyranothioxanthenones and their pyrazole-
fused derivatives, which bind to DNA, block the G 2+ M-phases of the cell cycle and inhibit …
fused derivatives, which bind to DNA, block the G 2+ M-phases of the cell cycle and inhibit …
Novel pyrrolopyrimidine derivatives induce p53-independent apoptosis via the mitochondrial pathway in colon cancer cells
Z Kilic-Kurt, Y Aka, O Kutuk - Chemico-Biological Interactions, 2020 - Elsevier
A series of novel pyrrolopyrimidine urea derivatives were synthesized and evaluated for
their anticancer activity against colon cancer cell lines. Compounds showed the remarkable …
their anticancer activity against colon cancer cell lines. Compounds showed the remarkable …
The cytotoxicity and mode of action of 2, 3, 4-trisubstituted pyrroles and related derivatives in human Tmolt4 leukemia cells
JT Gupton, BS Burham, BD Byrd… - Die …, 1999 - scholarship.richmond.edu
Carbechoxy-l-methyl-2-phenacyl-3-phenylpyrrole (9), 4-carbethoxy-2-(4-methoxybcnzoyl)-3-
(4-methoxyphcnyl) pyrrole (10) and 2-(4-methoxybenzoyl)-3, 4-bis-(4-methoxyphenyl) …
(4-methoxyphcnyl) pyrrole (10) and 2-(4-methoxybenzoyl)-3, 4-bis-(4-methoxyphenyl) …
Selective cytotoxic activities of two novel synthetic drugs on human breast carcinoma MCF-7 cells
RB Badisa, SF Darling-Reed, P Joseph… - Anticancer …, 2009 - ar.iiarjournals.org
Background: Breast cancer is the second leading cause of cancer deaths in US women. We
evaluated two novel compounds, piperidinyl-diethylstilbestrol (DES) and pyrrolidinyl …
evaluated two novel compounds, piperidinyl-diethylstilbestrol (DES) and pyrrolidinyl …
Synthesis and anticancer activity of aminodihydroquinoline analogs: Identification of novel proapoptotic agents
E Lee, SA Han, GH Jin, HJ Lee, WY Kim, JH Ryu… - Bioorganic & medicinal …, 2013 - Elsevier
A series of 2-aminodihydroquinoline analogs were synthesized and their in vitro
cytotoxicities against metastatic breast adenocarcinoma cell line MDA-MB-231 were tested …
cytotoxicities against metastatic breast adenocarcinoma cell line MDA-MB-231 were tested …
Tumor-specific cytotoxic activity of 1, 2, 3, 4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines
H Hatano, F Takekawa, K Hashimoto… - Anticancer …, 2009 - ar.iiarjournals.org
The tumor-specific cytotoxicity and the type of cell death induced by thirty-eight newly
synthesized tetrahydroisoquinoline derivatives in human oral squamous cell carcinoma cell …
synthesized tetrahydroisoquinoline derivatives in human oral squamous cell carcinoma cell …