The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Network-based biomarkers in Alzheimer's disease: review and future directions
J Gomez-Ramirez, J Wu - Frontiers in aging neuroscience, 2014 - frontiersin.org
By 2050 it is estimated that the number of worldwide Alzheimer's disease (AD) patients will
quadruple from the current number of 36 million people. To date, no single test, prior to …
quadruple from the current number of 36 million people. To date, no single test, prior to …
Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease
E Guzmán-Vélez, I Diez… - Proceedings of the …, 2022 - National Acad Sciences
The human brain is composed of functional networks that have a modular topology, where
brain regions are organized into communities that form internally dense (segregated) and …
brain regions are organized into communities that form internally dense (segregated) and …
Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Mapping the Alzheimer's brain with connectomics
T Xie, Y He - Frontiers in psychiatry, 2012 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. As an incurable,
progressive, and neurodegenerative disease, it causes cognitive and memory deficits …
progressive, and neurodegenerative disease, it causes cognitive and memory deficits …
Networks of tau distribution in Alzheimer's disease
Abstract See Whitwell (doi: 10.1093/brain/awy001) for a scientific commentary on this article.
A stereotypical anatomical propagation of tau pathology has been described in Alzheimer's …
A stereotypical anatomical propagation of tau pathology has been described in Alzheimer's …
[HTML][HTML] A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease
Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease
Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease
Recent advances toward the characterization of Alzheimer's disease (AD) have permitted
the identification of a dozen of genetic risk factors, although many more remain …
the identification of a dozen of genetic risk factors, although many more remain …
Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau
S Rayaprolu, L Higginbotham, P Bagchi… - …, 2021 - nature.com
The repeated failures of amyloid-targeting therapies have challenged our narrow
understanding of Alzheimer's disease (AD) pathogenesis and inspired wide-ranging …
understanding of Alzheimer's disease (AD) pathogenesis and inspired wide-ranging …