Effector Functions of Antiaquaporin‐4 Autoantibodies in Neuromyelitis Optica

R Cayrol, P Saikali, T Vincent - … of the New York Academy of …, 2009 - Wiley Online Library
NMO‐IgG autoantibody is now considered a useful serum biomarker of neuromyelitis optica
(NMO). A series of clinical and pathological observations suggest that NMO‐IgG may play a …

Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica

P Saikali, R Cayrol, T Vincent - Autoimmunity Reviews, 2009 - Elsevier
NMO-IgG, the auto-antibody specific to the aquaporin-4 (AQP4) water channel associated
with the autoimmune inflammatory disease neuromyelitis optica (NMO), is considered to be …

Neuromyelitis optica: diagnosis, pathogenesis, and treatment

B Cree - Current neurology and neuroscience reports, 2008 - Springer
Although the co-occurrence of myelitis and optic neuritis that characterizes neuromyelitis
optica (NMO) was recognized over a century ago, distinguishing NMO from multiple …

Neuromyelitis optica immunoglobulin G present in sera from neuromyelitis optica patients affects aquaporin‐4 expression and water permeability of the astrocyte …

L Melamud, JM Fernández, V Rivarola… - Journal of …, 2012 - Wiley Online Library
NMO‐IgG autoantibody selectively binds to aquaporin‐4 (AQP4), the most abundant water
channel in the central nervous system and is now considered a useful serum biomarker of …

The role of AQP4 in neuromyelitis optica: more answers, more questions

X Yang, BR Ransom, JF Ma - Journal of neuroimmunology, 2016 - Elsevier
Neuromyelitis optica (NMO) is a recurrent inflammatory disease that preferentially targets the
optic nerves and spinal cord. The presence of antibodies to the water channel protein …

Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica

N Isobe, T Yonekawa, T Matsushita, K Masaki… - Neurochemical …, 2013 - Springer
Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic
nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO …

[HTML][HTML] Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica

S Mader, A Lutterotti, F Di Pauli, B Kuenz, K Schanda… - PloS one, 2010 - journals.plos.org
Background Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself
with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG …

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

SR Hinson, SF Roemer, CF Lucchinetti… - The Journal of …, 2008 - rupress.org
Neuromyelitis optica (NMO)-immunoglobulin G (IgG) is a clinically validated serum
biomarker that distinguishes relapsing central nervous system (CNS) inflammatory …

[HTML][HTML] Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays

JM Crane, C Lam, A Rossi, T Gupta, JL Bennett… - Journal of Biological …, 2011 - ASBMB
Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for
the neuroinflammatory disease neuromyelitis optica (NMO). We measured the binding of …

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

S Jarius, B Wildemann - Nature Reviews Neurology, 2010 - nature.com
Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …