Chordomas are rare primary bone tumors that occur along the neuraxis. Primary treatment is
surgery, often followed by radiotherapy. Treatment options for patients with recurrence are …

Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord
with a close predilection for the axial skeleton. Recurrence is common and no effective …

Simple Summary We report the experience of our institution in treating clival chordomas
over 20 years and systematically review the recent literature, highlighting factors associated …

Background To report on a prospective, investigator-driven, phase II study on lapatinib in
epidermal growth factor receptor (EGFR)-positive advanced chordoma patients. Patients …

Chordoma is a rare malignant bone tumour with a poor prognosis and limited therapeutic
options. We undertook a focused compound screen (FCS) against 1097 compounds on …

The treatment of clival chordoma remains highly challenging. This difficulty is enhanced by
the very small likelihood of a successful complete surgical resection or nonsurgical …

Chordoma is a complex disease because of its rarity, biological heterogeneity and peculiar
clinical behaviour. Despite the progress done, the outcome in this disease remains …

Chordomas are rare neoplasms arising along the axial skeleton. Up to now, the most
suitable therapeutic approach is based on a combination of surgical excision and …

Purpose Chordoma is a rare neoplasm that arises from embryonic notochordal remnants
along the axial skeleton (ie, clivus, sacrum) and the vertebral bodies. They comprise less …

Chordoma is a rare bone tumor often present in the skull base and spine. In addition, it is not
sensitive to radiotherapy that surgical resection is of great significance for the treatment of …