Neuroinflammation during RNA viral infections

RS Klein, C Garber, KE Funk, H Salimi… - Annual review of …, 2019 - annualreviews.org
Neurotropic RNA viruses continue to emerge and are increasingly linked to diseases of the
central nervous system (CNS) despite viral clearance. Indeed, the overall mortality of viral …

Viral encephalitis and neurologic diseases: focus on astrocytes

A Soung, RS Klein - Trends in molecular medicine, 2018 - cell.com
Neurotropic RNA virus infections cause a major neurological disease burden. Due to the
morbidity and mortality rates of viral encephalitides worldwide, there is a need to develop …

Orchestration of antiviral responses within the infected central nervous system

A Pavlou, F Mulenge, OL Gern, LM Busker… - Cellular & molecular …, 2024 - nature.com
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring
viral encephalitis as a global research priority. Upon entry of the virus into the CNS, severe …

Keeping it in check: chronic viral infection and antiviral immunity in the brain

KD Miller, MJ Schnell, GF Rall - Nature Reviews Neuroscience, 2016 - nature.com
It is becoming clear that the manner by which the immune response resolves or contains
infection by a pathogen varies according to the tissue that is affected. Unlike many …

Molecular mechanisms associated with neurodegeneration of neurotropic viral infection

P Wongchitrat, T Chanmee, P Govitrapong - Molecular Neurobiology, 2024 - Springer
Viral infections of the central nervous system (CNS) cause variable outcomes from acute to
severe neurological sequelae with increased morbidity and mortality. Viral neuroinvasion …

Immune responses to RNA-virus infections of the CNS

DE Griffin - Nature Reviews Immunology, 2003 - nature.com
A successful outcome for the host of virus infection of the central nervous system (CNS)
requires the elimination of the virus without damage to essential non-renewable cells, such …

Illuminating viral infections in the nervous system

DB McGavern, SS Kang - Nature Reviews Immunology, 2011 - nature.com
Viral infections are a major cause of human disease. Although most viruses replicate in
peripheral tissues, some have developed unique strategies to move into the nervous …

Viral CNS infections: role of glial pattern recognition receptors in neuroinflammation

SR Furr, I Marriott - Frontiers in microbiology, 2012 - frontiersin.org
Viruses are the major causative agents of central nervous system (CNS) infection worldwide.
RNA and DNA viruses trigger broad activation of glial cells including microglia and …

Neural immunity: Friend or foe?

HE Gendelman - Journal of neurovirology, 2002 - Taylor & Francis
The articles compiled in this special edition of Journal of NeuroVirology target a developing
field of investigation seeking to uncover how the immune system affects both the pathogenic …

Infectious immunity in the central nervous system and brain function

RS Klein, C Garber, N Howard - Nature immunology, 2017 - nature.com
Inflammation is emerging as a critical mechanism underlying neurological disorders of
various etiologies, yet its role in altering brain function as a consequence of neuroinfectious …