Adenosine is a ubiquitous chemical messenger that modulates cellular activity in both the
CNS and peripheral organs. 1-5 Adenosine levels in the brain extracellular space increase …

Adenosine is a modulator of brain function uniquely positioned to integrate excitatory and
inhibitory neurotransmission. The past few years brought a wealth of new data fostering our …

Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …

The endogenous neuromodulator adenosine controls and integrates a wide range of brain
functions. Consequently, dysfunction of the adenosine system is involved in pathologies …

▪ Abstract Adenosine is a modulator that has a pervasive and generally inhibitory effect on
neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally …

Adenosine is a naturally occurring nucleoside present ubiquitously throughout the body as a
metabolic intermediate. Besides its metabolic role within the cells, adenosine is released …

Adenosine is present in the brain under physiological conditions and acts on G protein-
coupled receptors. Adenosine regulates neurotransmitter release and neuronal firing rate …

Adenosine is present in the extacellular space of organs and tissues in the mammalian
organism where it modulates a variety of physiological processes through specific cell …

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not
surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in …

Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly,
plays a complex role in multiple physiological and pathophysiological processes by …