Histone demethylation is a vital process in epigenetic regulation of gene expression. A
number of histone demethylases are present to control the methylated states of histone …

Introduction: As epigenetic modulators, histone demethylases can be a therapeutic target in
the area of oncology. KDM4 subfamily proteins are histone demethylases with a Jumonji …

Epigenetic enzyme-targeted therapy is a promising new development in the field of drug
discovery. To date, histone deacetylases and DNA methyltransferases have been …

The histone lysine demethylase 4 (KDM4) family plays an important role in regulating gene
transcription, DNA repair, and metabolism. The dysregulation of KDM4 functions is …

Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Highlights•The dysregulation of JmjC-KDMs is closely related with various human diseases,
especially cancers.•The structures and transcriptional regulation of JmjC-KDMs are …

Histone lysine demethylase 4D (KDM4D) plays an important role in the regulation of
tumorigenesis, progression and drug resistance and has been considered a potential target …

Abstract Lysine demethylase 5B (KDM5B) is a histone demethylase identified in 2007, which
is responsible for erasing H3K4me2/3 activation marker. It participates in multiple repressive …

Post-translational modifications (PTMs) of histone by histone demethylases (KDMs) play an
important role in the regulation of gene expression, which implicates the development of …