Accumulating evidence suggests that gut-microbiota metabolites contribute to human
disease pathophysiology, yet the host receptors that sense these metabolites are largely …

Shifts in the magnitude and nature of gut microbial metabolites have been implicated in
Alzheimer's disease (AD), but the host receptors that sense and respond to these …

Human-microorganism interactions play a key role in human health. However, the
underlying molecular mechanisms remain poorly understood. Small-molecules that offer a …

The gut microbiota (GM) and its metabolites affect the host nervous system and are involved
in the pathogeneses of various neurological diseases. However, the specific GM alterations …

Background Interactions between the gut microbiota, microglia, and aging may modulate
Alzheimer's disease (AD) pathogenesis but the precise nature of such interactions is not …

Background Alzheimer's disease (AD) is complex, with genetic, epigenetic, and
environmental factors contributing to disease susceptibility and progression. While …

Complementary alternative medicine approaches are growing treatments of diseases to
standard medicine practice. Many of these concepts are being adopted into standard …

The human body contains thousands of metabolites derived from mammalian cells, the
microbiota, food, and medical drugs. Many bioactive metabolites act through the …

The prebiotic potential of nervine herbal medicines has been scarcely studied. We therefore
used anaerobic human fecal cultivation to investigate whether medicinal herbs commonly …

Due to the aging of the world population and westernization of lifestyles, the prevalence of
neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease …