The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding,
but it also has an important role in sensing cellular stress. Recently, it has been shown that …

In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of
proteins that enter the secretory pathway. Environmental insults or increased protein …

Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is
observed in many physiological and pathological conditions. To cope with endoplasmic …

The endoplasmic reticulum (ER) is a major site of protein synthesis, most strikingly in the
specialized secretory cells of metazoans, which can produce their own weight in proteins …

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a
cellular stress induced by multiple stimuli and pathological conditions. These include …

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of
homeostasis causes stress. In this review I summarize how perturbation of three major …

The recent elucidation of the mammalian unfolded protein response pathway has revealed a
unique and transcriptionally complex signal transduction pathway that protects cells from a …

Many exogenous sources of stress can lead to cell death. In recent years, endogenous
cellular sources of stress have also been identified, including the stress that arises from the …

The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and
secretory proteins, which, collectively, represent a large fraction of the total protein output of …

The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and
transmembrane proteins are assembled and folded into their correct tertiary structures …