Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse
MR Lowerison, NVC Sekaran, W Zhang, Z Dong… - Scientific reports, 2022 - nature.com
Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …
unifying mechanism has been identified for the cognitive impairments seen in an aging …
In vivo pulsatility measurement of cerebral microcirculation in rodents using dynamic ultrasound localization microscopy
An increased pulse pressure, due to arteries stiffening with age and cardiovascular disease,
may lead to downstream brain damage in microvessels and cognitive decline. Brain-wide …
may lead to downstream brain damage in microvessels and cognitive decline. Brain-wide …
In vivo whole brain microvascular imaging in mice using transcranial 3D ultrasound localization microscopy
Background Non-invasive high-resolution imaging of the cerebral vascular anatomy and
function is key for the study of intracranial aneurysms, stenosis, arteriovenous …
function is key for the study of intracranial aneurysms, stenosis, arteriovenous …
Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale
The advent of neuroimaging has increased our understanding of brain function. While most
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …
Volumetric ultrasound localization microscopy of the whole rat brain microvasculature
B Heiles, A Chavignon, A Bergel… - IEEE Open Journal …, 2022 - ieeexplore.ieee.org
Technologies to visualize whole organs across scales in vivo are essential for our
understanding of biology in health and disease. To date, only post-mortem techniques …
understanding of biology in health and disease. To date, only post-mortem techniques …
[HTML][HTML] Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and …
Á Nyúl-Tóth, S Tarantini, J DelFavero… - American Journal …, 2021 - journals.physiology.org
Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction
contribute importantly to the pathogenesis of both vascular cognitive impairment and …
contribute importantly to the pathogenesis of both vascular cognitive impairment and …
Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients
Abstract Changes in cerebral blood flow are associated with stroke, aneurysms, vascular
cognitive impairment, neurodegenerative diseases and other pathologies. Brain …
cognitive impairment, neurodegenerative diseases and other pathologies. Brain …
Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease
B Malojcic, P Giannakopoulos, FA Sorond, E Azevedo… - BMC medicine, 2017 - Springer
Background The vascular contributions to neurodegeneration and neuroinflammation may
be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review …
be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review …
[HTML][HTML] Non-invasive transcranial volumetric ultrasound localization microscopy of the rat brain with continuous, high volume-rate acquisition
Rationale: Structure and function of the microvasculature provides critical information about
disease state, can be used to identify local regions of pathology, and has been shown to be …
disease state, can be used to identify local regions of pathology, and has been shown to be …
Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice
In age-related neurodegenerative diseases, pathology often develops slowly across the
lifespan. As one example, in diseases such as Alzheimer's, vascular decline is believed to …
lifespan. As one example, in diseases such as Alzheimer's, vascular decline is believed to …